干旱区生态环境知识资源中心(Arid): Rapid Simultaneous Determination of 11 Synthetic Cannabinoids in Urine by Liquid Chromatography-Triple Quadrupole Mass Spectrometry

Arid

DOI	10.3390/separations10030203
	Rapid Simultaneous Determination of 11 Synthetic Cannabinoids in Urine by Liquid Chromatography-Triple Quadrupole Mass Spectrometry
	Wu, Jianbing; Zhang, Fan; Ke, Xing; Jia, Wei; Wan, Xuzhi; Zhang, Lange; Fan, Yilei; Zhou, Jing
通讯作者	Zhou, J
来源期刊	SEPARATIONS
EISSN	2297-8739
出版年	2023
卷号	10 期号:3
英文摘要	Synthetic cannabinoids are a series of synthetic substances that mimic the effects of natural cannabinoids and produce a much stronger toxicity than natural cannabinoids, and they have become the most abused family of new psychoactive substances. A solid-phase extraction-liquid chromatography-triple quadrupole/linear ion trap mass spectrometry method has been developed to determine 11 synthetic cannabinoids in rat urine. Oasis HLB cartridge was selected to simultaneously extract synthetic cannabinoids for pretreatment. The effects of the loading solution and elution reagent volume on the recovery were investigated. The optimized acetonitrile proportion and elution reagent volume were determined by both high recovery and low solvent consumption. The results showed that the linear coefficients of determination of 11 types of synthetic cannabinoids ranged from 0.993 to 0.999, the limit of quantitation ranged from 0.01 to 0.1 ng/mL, and the spiked recoveries ranged from 69.90% to 118.39%. The research presented here provides a validated liquid chromatography tandem mass spectrometry method to accurately identify and quantitate synthetic cannabinoid metabolites in urine samples.
英文关键词	synthetic cannabinoids LC-MS MS simultaneous determination quantitative analysis urine
类型	Article
语种	英语
开放获取类型	Green Submitted, gold
收录类别	SCI-E
WOS记录号	WOS:000956816500001
WOS关键词	SEIZED MATERIALS ; MS/MS METHOD ; BLOOD ; VALIDATION ; QUALITY ; SAMPLES
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/398646
推荐引用方式 GB/T 7714	Wu, Jianbing,Zhang, Fan,Ke, Xing,et al. Rapid Simultaneous Determination of 11 Synthetic Cannabinoids in Urine by Liquid Chromatography-Triple Quadrupole Mass Spectrometry[J],2023,10(3).
APA	Wu, Jianbing.,Zhang, Fan.,Ke, Xing.,Jia, Wei.,Wan, Xuzhi.,...&Zhou, Jing.(2023).Rapid Simultaneous Determination of 11 Synthetic Cannabinoids in Urine by Liquid Chromatography-Triple Quadrupole Mass Spectrometry.SEPARATIONS,10(3).
MLA	Wu, Jianbing,et al."Rapid Simultaneous Determination of 11 Synthetic Cannabinoids in Urine by Liquid Chromatography-Triple Quadrupole Mass Spectrometry".SEPARATIONS 10.3(2023).