干旱区生态环境知识资源中心(Arid): A selective dual quenching sensor (EY/BG@CDs) for simultaneous monitoring of gentamicin and ketorolac levels in plasma: a highly efficient platform that caters to the needs of therapeutic drug monitoring

Arid

DOI	10.1039/d3ra04894b
	A selective dual quenching sensor (EY/BG@CDs) for simultaneous monitoring of gentamicin and ketorolac levels in plasma: a highly efficient platform that caters to the needs of therapeutic drug monitoring
	Alhazzani, Khalid; Alanazi, Ahmed Z.; Mostafa, Aya M.; Barker, James; El-Wekil, Mohamed M.; Bellah H. Ali, Al-Montaser
通讯作者	Ali, ABH
来源期刊	RSC ADVANCES
EISSN	2046-2069
出版年	2023
卷号	13 期号:41 页码:28940-28950
英文摘要	This research work introduces a novel sensor that utilizes two fluorophores to enable simultaneous monitoring of gentamicin sulphate (GNT) and ketorolac tromethamine (KET). The innovative sensor is composed of carbon dots (CDs) derived from black grapes (BG) and eosin Y (EY) dye. The interaction between the studied drugs and EY/BG@CDs sensor components allows for their simultaneous detection where GNT quenches the fluorescence of EY at 535 nm without affecting the fluorescence of CDs, while KET quenches the fluorescence of BG@CDs at 385 nm without impacting EY fluorescence. The BG@CDs probe was successfully characterized using various techniques such as absorption spectrophotometry, spectrofluorimetry, TEM imaging, infrared spectroscopic analysis, and XRD analysis. The suggested methodology was observed to be highly sensitive for the simultaneous determination of GNT and KET in their spiked rabbit plasma samples, with wide linear ranges and low limit of detection (LOD) values. The studied drugs were extracted using a highly selective extraction method involving protein precipitation followed by mixed mode solid phase extraction using an Oasis WCX cartridge. The simultaneous determination of GNT and KET is essential due to the potential interactions between the studied drugs. Therefore, this analysis can be used to evaluate the necessity of dose monitoring and the potential adverse effects of co-administration of these drugs. This research work introduces a novel sensor that utilizes two fluorophores to enable simultaneous monitoring of gentamicin sulphate (GNT) and ketorolac tromethamine (KET).
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:001076638100001
WOS关键词	DOPED CARBON DOTS ; SPECTROFLUOROMETRIC DETERMINATION ; PHARMACEUTICAL-PREPARATIONS ; FLUOROMETRIC-DETERMINATION ; CAPILLARY-ELECTROPHORESIS ; ELECTROCHEMICAL DETECTION ; LIQUID ; PHASE ; TROMETHAMINE
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/398450
推荐引用方式 GB/T 7714	Alhazzani, Khalid,Alanazi, Ahmed Z.,Mostafa, Aya M.,et al. A selective dual quenching sensor (EY/BG@CDs) for simultaneous monitoring of gentamicin and ketorolac levels in plasma: a highly efficient platform that caters to the needs of therapeutic drug monitoring[J],2023,13(41):28940-28950.
APA	Alhazzani, Khalid,Alanazi, Ahmed Z.,Mostafa, Aya M.,Barker, James,El-Wekil, Mohamed M.,&Bellah H. Ali, Al-Montaser.(2023).A selective dual quenching sensor (EY/BG@CDs) for simultaneous monitoring of gentamicin and ketorolac levels in plasma: a highly efficient platform that caters to the needs of therapeutic drug monitoring.RSC ADVANCES,13(41),28940-28950.
MLA	Alhazzani, Khalid,et al."A selective dual quenching sensor (EY/BG@CDs) for simultaneous monitoring of gentamicin and ketorolac levels in plasma: a highly efficient platform that caters to the needs of therapeutic drug monitoring".RSC ADVANCES 13.41(2023):28940-28950.