干旱区生态环境知识资源中心(Arid): Economic Burden of Idiopathic Pulmonary Fibrosis in Spain: A Prospective Real-World Data Study (OASIS Study)

Arid

DOI	10.1007/s40273-023-01278-3
	Economic Burden of Idiopathic Pulmonary Fibrosis in Spain: A Prospective Real-World Data Study (OASIS Study)
	Rodriguez-Nieto, Maria Jesus; Cano-Jimenez, Esteban; Romero Ortiz, Ana D.; Villar, Ana; Morros, Marta; Ramon, Alba; Armengol, Silvia
通讯作者	Rodríguez-Nieto, MJ
来源期刊	PHARMACOECONOMICS
ISSN	1170-7690
EISSN	1179-2027
出版年	2023
卷号	41 期号:8 页码:999-1010
英文摘要	BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease associated with dyspnoea, cough and impaired quality of life affecting around 7500 patients in Spain.ObjectiveOur aim was to estimate the economic impact of IPF according to forced vital capacity (FVC) % predicted level in adult patients.MethodsWe conducted a prospective, observational, multicentric study of patients with confirmed IPF in Spain. Total annual IPF-related costs were estimated per patient, and categorised according to the FVC% predicted value (FVC < 50%, FVC 50-80%, FVC > 80%) and total sample. Incurred direct health- and non-health-related costs and indirect costs were calculated considering the IPF-related healthcare resource use and the corresponding unitarian costs. Results were updated to 2023 euros.ResultsTwo hundred and four consecutive patients with IPF were included: 77% male, average age (standard deviation) 70.8 (7.6) years. At baseline, FVC% was < 50%, 50-80% and > 80% of predicted value in 10.8%, 74.5% and 14.7% of patients, respectively. The final cost-evaluable population included 180 subjects. The mean (standard deviation) total annual IPF-related cost was euro26,997 (17,555), with statistically significant differences (p = 0.0002) between groups: euro44,412 (33,389) for the FVC < 50%, euro25,803 (14,688) for the FVC 50-80% and euro23,242 (13,642) for the FVC > 80%. Annual direct health costs had the greatest weight and included pharmacological treatments [euro22,324 (13,773)] and hospitalisation days [euro1659 (7362)]. 14 patients had >= 1 acute exacerbation of IPF during the study; mean total cost of an acute exacerbation of IPF was euro10,372. According to the multivariate analysis, an impaired lung function (FVC < 50%) and use of antifibrotic treatment were determinants of cost (p < 0.0001 both).ConclusionsWe observed a significantly higher annual IPF-related cost at a lower level of predicted FVC%, the direct cost having the greatest weight to the total costs. Maintaining patients at early disease stages by slowing IPF progression is relevant to reduce the economic impact of IPF.
类型	Article
语种	英语
开放获取类型	hybrid, Green Published
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000997624600001
WOS关键词	ACUTE EXACERBATION ; CLINICAL-COURSE ; NINTEDANIB ; PREDICTION ; GUIDELINES ; DIAGNOSIS ; SURVIVAL ; EFFICACY ; CARE
WOS类目	Economics ; Health Care Sciences & Services ; Health Policy & Services ; Pharmacology & Pharmacy
WOS研究方向	Business & Economics ; Health Care Sciences & Services ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/397993
推荐引用方式 GB/T 7714	Rodriguez-Nieto, Maria Jesus,Cano-Jimenez, Esteban,Romero Ortiz, Ana D.,et al. Economic Burden of Idiopathic Pulmonary Fibrosis in Spain: A Prospective Real-World Data Study (OASIS Study)[J],2023,41(8):999-1010.
APA	Rodriguez-Nieto, Maria Jesus.,Cano-Jimenez, Esteban.,Romero Ortiz, Ana D..,Villar, Ana.,Morros, Marta.,...&Armengol, Silvia.(2023).Economic Burden of Idiopathic Pulmonary Fibrosis in Spain: A Prospective Real-World Data Study (OASIS Study).PHARMACOECONOMICS,41(8),999-1010.
MLA	Rodriguez-Nieto, Maria Jesus,et al."Economic Burden of Idiopathic Pulmonary Fibrosis in Spain: A Prospective Real-World Data Study (OASIS Study)".PHARMACOECONOMICS 41.8(2023):999-1010.