干旱区生态环境知识资源中心(Arid): Functional alterations in bipartite network of white and grey matters during aging

Arid

DOI	10.1016/j.neuroimage.2023.120277
	Functional alterations in bipartite network of white and grey matters during aging
	Gao, Yurui; Zhao, Yu; Li, Muwei; Lawless, Richard D.; Schilling, Kurt G.; Xu, Lyuan; Shafer, Andrea T.; Beason-Held, Lori L.; Resnick, Susan M.; Rogers, Baxter P.; Ding, Zhaohua; Anderson, Adam W.; Landman, Bennett A.; Gore, John C.
通讯作者	Gao, YR ; Gore, JC
来源期刊	NEUROIMAGE
ISSN	1053-8119
EISSN	1095-9572
出版年	2023
卷号	278
英文摘要	The effects of normal aging on functional connectivity (FC) within various brain networks of gray matter (GM) have been well-documented. However, the age effects on the networks of FC between white matter (WM) and GM, namely WM-GM FC, remains unclear. Evaluating crucial properties, such as global efficiency (GE), for a WM-GM FC network poses a challenge due to the absence of closed triangle paths which are essential for assessing network properties in traditional graph models. In this study, we propose a bipartite graph model to characterize the WM-GM FC network and quantify these challenging network properties. Leveraging this model, we assessed the WM-GM FC network properties at multiple scales across 1,462 cognitively normal subjects aged 22-96 years from three repositories (ADNI, BLSA and OASIS-3) and investigated the age effects on these properties throughout adulthood and during late adulthood (age & GE;70 years). Our findings reveal that (1) heterogeneous alterations occurred in region-specific WM-GM FC over the adulthood and decline predominated during late adulthood; (2) the FC density of WM bundles engaged in memory, executive function and processing speed declined with age over adulthood, particularly in later years; and (3) the GE of attention, default, somatomotor, frontoparietal and limbic networks reduced with age over adulthood, and GE of visual network declined during late adulthood. These findings provide unpresented insights into multi-scale alterations in networks of WM-GM functional synchronizations during normal aging. Furthermore, our bipartite graph model offers an extendable framework for quantifying WM-engaged networks, which may contribute to a wide range of neuroscience research.
英文关键词	White matter Resting state FMRI Functional connectivity Bipartite graph Normal aging Adulthood
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:001059198300001
WOS关键词	ANTERIOR CINGULATE ; CEREBRAL-BLOOD ; BRAIN ACTIVITY ; CONNECTIVITY ; AGE ; ATLAS ; FMRI ; DEFAULT ; DECLINE ; SYSTEMS
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/397907
推荐引用方式 GB/T 7714	Gao, Yurui,Zhao, Yu,Li, Muwei,et al. Functional alterations in bipartite network of white and grey matters during aging[J],2023,278.
APA	Gao, Yurui.,Zhao, Yu.,Li, Muwei.,Lawless, Richard D..,Schilling, Kurt G..,...&Gore, John C..(2023).Functional alterations in bipartite network of white and grey matters during aging.NEUROIMAGE,278.
MLA	Gao, Yurui,et al."Functional alterations in bipartite network of white and grey matters during aging".NEUROIMAGE 278(2023).