干旱区生态环境知识资源中心(Arid): Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study

Arid

DOI	10.1016/j.neuroimage.2023.120146
	Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study
	Liu, Guodong; Shen, Chenye; Qiu, Anqi
通讯作者	Qiu, AQ
来源期刊	NEUROIMAGE
ISSN	1053-8119
EISSN	1095-9572
出版年	2023
卷号	275
英文摘要	The brain undergoes many changes at pathological and functional levels in healthy aging. This study employed a longitudinal and multimodal imaging dataset from the OASIS-3 study (n = 300) and explored possible relationships between amyloid beta (A beta) accumulation and functional brain organization over time in healthy aging. We used positron emission tomography (PET) with Pittsburgh compound-B (PIB) to quantify the A beta accumulation in the brain and resting-state functional MRI (rs-fMRI) to measure functional connectivity (FC) among brain regions. Each participant had at least 2 to 3 follow-up visits. A linear mixed-effect model was used to examine longitudinal changes of A beta accumulation and FC throughout the whole brain. We found that the limbic and frontoparietal networks had a greater annual A beta accumulation and a slower decline in FC in aging. Additionally, the amount of the A beta deposition in the amygdala network at baseline slowed down the decline in its FC in aging. Furthermore, the functional connectivity of the limbic, default mode network (DMN), and frontoparietal networks accelerated the A beta propagation across their functionally highly connected regions. The functional connectivity of the somatomotor and visual networks accelerated the A beta propagation across the brain regions in the limbic, frontoparietal, and DMN networks. These findings suggested that the slower decline in the functional connectivity of the functional hubs may compensate for their greater A beta accumulation in aging. The A beta propagation from one brain region to the other may depend on their functional connectivity strength.
英文关键词	Amyloid deposition Functional brain organization Positron emission tomography Resting-state FMRI Brain aging Functional connectivity
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000999129500001
WOS关键词	MILD COGNITIVE IMPAIRMENT ; PARTIAL VOLUME CORRECTION ; ALZHEIMERS-DISEASE ; A-BETA ; BRAIN ; NETWORK ; HUBS ; DEPOSITION ; PET ; IMPLEMENTATION
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/397906
推荐引用方式 GB/T 7714	Liu, Guodong,Shen, Chenye,Qiu, Anqi. Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study[J],2023,275.
APA	Liu, Guodong,Shen, Chenye,&Qiu, Anqi.(2023).Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study.NEUROIMAGE,275.
MLA	Liu, Guodong,et al."Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study".NEUROIMAGE 275(2023).