干旱区生态环境知识资源中心(Arid): Cold-induced adaptive thermogenesis is impaired by exposure of Asian sand dust in mice

Arid

DOI	10.1016/j.jtherbio.2023.103675
	Cold-induced adaptive thermogenesis is impaired by exposure of Asian sand dust in mice
	Bagon, Bernadette B.; Lee, Junhyeong; Matienzo, Merc Emil; Lee, Se-Jin; Pak, So-Won; Kim, Keon; Lee, Jeongmin; Lee, Chang-Min; Shin, In -Sik; Moon, Changjong; Park, Min -Jung; Kim, Dong -il
通讯作者	Park, MJ ; Kim, DI
来源期刊	JOURNAL OF THERMAL BIOLOGY
ISSN	0306-4565
EISSN	1879-0992
出版年	2023
卷号	116
英文摘要	Desertification and desert sandstorms caused by the worsening global warming pose increasing risks to human health. In particular, Asian sand dust (ASD) exposure has been related to an increase in mortality and hospital admissions for respiratory diseases. In this study, we investigated the effects of ASD on metabolic tissues in comparison to diesel particulate matter (DPM) that is known to cause adverse health effects. We found that larger lipid droplets were accumulated in the brown adipose tissues (BAT) of ASD-administered but not DPMadministered mice. Thermogenic gene expression was decreased in these mice as well. When ASDadministered mice were exposed to the cold, they failed to maintain their body temperature, suggesting that the ASD administration had led to impairments in cold-induced adaptive thermogenesis. However, impaired thermogenesis was not observed in DPM-administered mice. Furthermore, mice fed a high-fat diet that were chronically administered ASD demonstrated unexplained weight loss, indicating that chronic administration of ASD could be lethal in obese mice. We further identified that ASD-induced lung inflammation was not exacerbated in uncoupling protein 1 knockout mice, whose thermogenic capacity is impaired. Collectively, ASD exposure can impair cold-induced adaptive thermogenic responses in mice and increase the risk of mortality in obese mice.
英文关键词	Asian sand dust Thermogenesis brown adipose tissue Ucp1 Obesity Cold exposure
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:001090374000001
WOS关键词	BROWN ADIPOSE-TISSUE ; DIESEL EXHAUST PARTICLES ; HDL CHOLESTEROL ; DESERT DUST ; BEIGE FAT ; UCP1 ; INFLAMMATION ; ADIPOCYTES ; PULMONARY ; TRANSPORT
WOS类目	Biology ; Zoology
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Zoology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/397595
推荐引用方式 GB/T 7714	Bagon, Bernadette B.,Lee, Junhyeong,Matienzo, Merc Emil,et al. Cold-induced adaptive thermogenesis is impaired by exposure of Asian sand dust in mice[J],2023,116.
APA	Bagon, Bernadette B..,Lee, Junhyeong.,Matienzo, Merc Emil.,Lee, Se-Jin.,Pak, So-Won.,...&Kim, Dong -il.(2023).Cold-induced adaptive thermogenesis is impaired by exposure of Asian sand dust in mice.JOURNAL OF THERMAL BIOLOGY,116.
MLA	Bagon, Bernadette B.,et al."Cold-induced adaptive thermogenesis is impaired by exposure of Asian sand dust in mice".JOURNAL OF THERMAL BIOLOGY 116(2023).