干旱区生态环境知识资源中心(Arid): seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe)

Arid

DOI	10.1021/acs.jnatprod.2c01037
	seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe)
	Xue, Yongbo; Savchenko, Andrei I.; Agnew-Francis, Kylie A.; Miles, Jared A.; Holt, Tina; Lu, Hieng; Chow, Sharon; Forster, Paul I.; Boyle, Glen M.; Ross, Benjamin P.; Fischer, Katja; Kutateladze, Andrei G.; Williams, Craig M.
通讯作者	Williams, CM
来源期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
EISSN	1520-6025
出版年	2023
卷号	86 期号:3 页码:490-497
英文摘要	Cynanchum viminale subsp. australe, more commonly known as caustic vine, is a leafless succulent that grows in the northern arid zone of Australia. Toxicity toward livestock has been reported for this species, along with use in traditional medicine and its potential anticancer activity. Disclosed herein are novel seco-pregnane aglycones cynavimigenin A (5) and cynaviminoside A (6), together with new pregnane glycosides cynaviminoside B (7) and cynavimigenin B (8). Cynavimigenin B (8) contains an unprecedented 7-oxobicyclo[2.2.1]-heptane moiety in the seco-pregnane series, likely arising from a pinacol-type rearrangement. Interestingly, these isolates displayed only limited cytotoxicity in cancer and normal human cell lines, in addition to low activity against acetylcholinesterase and Sarcoptes scabiei bioassays, suggesting that 5-8 are not associated with the reported toxicity of this plant species.
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000958261300001
WOS关键词	C-21 STEROIDAL GLYCOSIDES ; PLANTS
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/397495
推荐引用方式 GB/T 7714	Xue, Yongbo,Savchenko, Andrei I.,Agnew-Francis, Kylie A.,et al. seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe)[J],2023,86(3):490-497.
APA	Xue, Yongbo.,Savchenko, Andrei I..,Agnew-Francis, Kylie A..,Miles, Jared A..,Holt, Tina.,...&Williams, Craig M..(2023).seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe).JOURNAL OF NATURAL PRODUCTS,86(3),490-497.
MLA	Xue, Yongbo,et al."seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe)".JOURNAL OF NATURAL PRODUCTS 86.3(2023):490-497.