干旱区生态环境知识资源中心(Arid): Antinociceptive and anti-inflammatory activities of essential oil of the leaves of Amburana cearensis (Allemao) AC Smith. from the semi-arid region of Northeastern Brazil

Arid

DOI	10.1016/j.jep.2023.116858
	Antinociceptive and anti-inflammatory activities of essential oil of the leaves of Amburana cearensis (Allemao) AC Smith. from the semi-arid region of Northeastern Brazil
	Veras, Bruno Oliveira; Moura, Geovanna Maria de Medeiros; de Barros, Amanda Vieira; da Silva, Marcia Vanusa; de Assis, Priscilla Anne Castro; de Aguiar, Julio Cesar Ribeiro de Oliveira Farias; Navarro, Daniela Maria do Amaral Ferraz; Ximenes, Rafael Matos; Wanderley, Almir Goncalves; de Oliveira, Maria Betania Melo; Lopes, Ana Catarina de Sousa
通讯作者	Veras, BO
来源期刊	JOURNAL OF ETHNOPHARMACOLOGY
ISSN	0378-8741
EISSN	1872-7573
出版年	2023
卷号	317
英文摘要	Ethnopharmacological relevance: Amburana cearensis (Allema & SIM;o) A.C. Smith is a medicinal plant with wide distri-bution in South America, popularly known in Brazil as cumaru or amburana de cheiro. In folk medicine, in the semi-arid region of Northeastern Brazil, infusions, teas and decoctions of leaves of Amburana cearensis have their practical use for treating fever, gastrointestinal disorders, inflammation, and inflammation pain. However, none of the ethnopharmacological properties has been scientifically evaluated using volatile compounds obtained from its leaves (essential oil).Aim of the study: This study investigated the chemical composition, acute oral toxicity, and antinociceptive and anti-inflammatory activities of the essential oil from the leaves of A. cearensis.Material and methods: The acute toxicity of the essential oil was investigated in mice. The antinociceptive effect was evaluated using the formalin test and, abdominal writhing induced by acetic acid, being investigated the possible mechanisms of action involved in antinociception. The acute anti-inflammatory effect was investigated through models of carrageenan-induced peritonitis, yeast-induced pyrexia, and carrageenan-and histamine-induced paw inflammation.Results: No acute toxicity was observed at doses up to 2000 mg/kg; p.o. The antinociceptive effect was statis-tically equal to morphine. In the formalin assay, the oil showed analgesic activity in the neurogenic and in-flammatory phases, having as mechanisms the cholinergic, adenosinergic system, and ATP-sensitive potassium channels (K-ATP). In peritonitis, a reduction in TNF-& alpha; and IL-1 & beta; levels and leukocyte migration were observed. The antipyretic effect was statistically superior to dipyrone. The reduction in paw edema was statistically su-perior to the standard in both models.Conclusion: The results obtained not only support the traditional use of the species in inflammatory conditions and pain in folk medicine but also demonstrate that this is a rich source of phytocomponents such as germacrone, which can be used as a natural and sustainable therapeutic agent with industrial applications.
英文关键词	Cumaru Essential oil Fabaceae Inflammation Ethnopharmacological Medicinal plant
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:001039450100001
WOS关键词	MEDICINAL-PLANTS ; CHEMICAL-COMPOSITION ; BETA-CARYOPHYLLENE ; FORMALIN TEST ; CHRONIC PAIN ; PAW EDEMA ; CONSTITUENTS ; CYCLOOXYGENASES ; SESQUITERPENES ; MUNICIPALITY
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/397313
推荐引用方式 GB/T 7714	Veras, Bruno Oliveira,Moura, Geovanna Maria de Medeiros,de Barros, Amanda Vieira,et al. Antinociceptive and anti-inflammatory activities of essential oil of the leaves of Amburana cearensis (Allemao) AC Smith. from the semi-arid region of Northeastern Brazil[J],2023,317.
APA	Veras, Bruno Oliveira.,Moura, Geovanna Maria de Medeiros.,de Barros, Amanda Vieira.,da Silva, Marcia Vanusa.,de Assis, Priscilla Anne Castro.,...&Lopes, Ana Catarina de Sousa.(2023).Antinociceptive and anti-inflammatory activities of essential oil of the leaves of Amburana cearensis (Allemao) AC Smith. from the semi-arid region of Northeastern Brazil.JOURNAL OF ETHNOPHARMACOLOGY,317.
MLA	Veras, Bruno Oliveira,et al."Antinociceptive and anti-inflammatory activities of essential oil of the leaves of Amburana cearensis (Allemao) AC Smith. from the semi-arid region of Northeastern Brazil".JOURNAL OF ETHNOPHARMACOLOGY 317(2023).