干旱区生态环境知识资源中心(Arid): Novel biomonitoring method for determining five classes of legacy and alternative flame retardants in human serum samples

Arid

DOI	10.1016/j.jes.2022.09.020
	Novel biomonitoring method for determining five classes of legacy and alternative flame retardants in human serum samples
	Guan, Xiaolin; Zhang, Gaoxin; Meng, Lingling; Liu, Mei; Zhang, Liyuan; Zhao, Chuxuan; Li, Yingming; Zhang, Qinghua; Jiang, Guibin
通讯作者	Li, YM
来源期刊	JOURNAL OF ENVIRONMENTAL SCIENCES
ISSN	1001-0742
EISSN	1878-7320
出版年	2023
卷号	131 页码:111-122
英文摘要	Flame retardants (FRs) are ubiquitous in environment and biota and may pose harm to hu-man health. In recent years, concern regarding legacy and alternative FRs has been inten-sified due to their widespread production and increasing contamination in environmental and human matrices. In this study, we developed and validated a novel analytical method for simultaneous determination of legacy and alternative FRs, including polychlorinated naphthalenes (PCNs), short-and middle-chain chlorinated paraffins (SCCPs and MCCPs), novel brominated flame retardants (NBFRs), and organophosphate esters (OPEs) in human serum. Serum samples were prepared by liquid-liquid extraction using ethyl acetate, and purified with Oasis (R) HLB cartridge and Florisil-silica gel columns. Instrumental analyses were carried out using gas chromatography-triple quadrupole mass spectrometry, high -resolution gas chromatography coupled with high-resolution mass spectrometry, and gas chromatography coupled with quadrupole time-of-flight mass spectrometry, respectively. The proposed method was validated for linearity, sensitivity, precision, accuracy, and matrix effects. Method detection limits for NBFRs, OPEs, PCNs, SCCPs, and MCCPs were 4.6 x 10 -4 - 8.6 x 10 -2 , 4.3 x 10 -3 -1.3, 1.1 x 10 -5 -1.0 x 10 -4 , 1.5, and 9.0 x 10 -1 ng mL -1 , respectively. Matrix spike recoveries ranged from 73%-122%, 71%-124%, 75%-129%, 92%-126%, and 94%-126% for NBFRs, OPEs, PCNs, SCCPs, and MCCPs, respectively. The analytical method was applied for detection of real human serum. CPs were the dominant FRs in serum, indicating CPs were widely presented in human serum and should be pay more attention for their health risk.(c) 2022 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
英文关键词	Human serum Biomonitoring Novel brominated flame retardants Organophosphate esters Chlorinated paraffins Polychlorinated naphthalenes
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000901837900010
WOS关键词	POLYBROMINATED DIPHENYL ETHERS ; CHAIN CHLORINATED PARAFFINS ; POLYCHLORINATED NAPHTHALENES ; HUMAN EXPOSURE ; ORGANOPHOSPHATE ESTERS ; ATMOSPHERIC EMISSION ; MASS-SPECTROMETRY ; LIPID-CONTENT ; CHINA ; DISTRIBUTIONS
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/397309
推荐引用方式 GB/T 7714	Guan, Xiaolin,Zhang, Gaoxin,Meng, Lingling,et al. Novel biomonitoring method for determining five classes of legacy and alternative flame retardants in human serum samples[J],2023,131:111-122.
APA	Guan, Xiaolin.,Zhang, Gaoxin.,Meng, Lingling.,Liu, Mei.,Zhang, Liyuan.,...&Jiang, Guibin.(2023).Novel biomonitoring method for determining five classes of legacy and alternative flame retardants in human serum samples.JOURNAL OF ENVIRONMENTAL SCIENCES,131,111-122.
MLA	Guan, Xiaolin,et al."Novel biomonitoring method for determining five classes of legacy and alternative flame retardants in human serum samples".JOURNAL OF ENVIRONMENTAL SCIENCES 131(2023):111-122.