干旱区生态环境知识资源中心(Arid): m6A regulator-mediated methylation modification highlights immune infiltration patterns for predicting risk in hepatocellular carcinoma

Arid

DOI	10.1007/s00432-022-04255-z
	m6A regulator-mediated methylation modification highlights immune infiltration patterns for predicting risk in hepatocellular carcinoma
	Zhou, Dongkai; Wang, Yizhi; Wei, Wei; Zhou, Wei; Gu, Jin; Kong, Yang; Yang, Qifan; Wu, Yingsheng
通讯作者	Wu, YS
来源期刊	JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
ISSN	0171-5216
EISSN	1432-1335
出版年	2023
卷号	149 期号:7 页码:3661-3680
英文摘要	Background Increasing studies have demonstrated the biological function of RNA N6-methyladenosine (m6A) modifications in tumorigenesis. However, the potential role of m6A modifications in the tumor immune microenvironment (TIME) of hepatocellular carcinoma (HCC) remains unclear. Methods Herein, 23 m6A regulators were fetched and introduced into consensus clustering to identify distinct m6A modification patterns and develop m6A-based molecular signatures. Then, a principal component analysis algorithm was employed to construct an m6A-based scoring system to further quantify m6A modification patterns in individual tumors. Immunophenoscore (IPS) was used to estimate the immunotherapeutic response of patients. Results Three different m6A modification patterns with distinct prognoses and biological signatures were identified among 611 HCC samples. The TIME characteristics of these three patterns were consistent with three known immune profiles: immune-oasis, immune-excluded, and immune-inflamed phenotypes. Identifying m6A modification patterns within individual tumors based on the m6Ascore, developed under the m6A-related signature genes, contributed to elaborating biological processes, clinical outcomes, immune cell infiltration, immunotherapeutic effects, and genetic variations. The low-m6Ascore subtype, characterized by immunosuppression, suggested an immune-suppressed phenotype and a low probability of benefiting from immunotherapy. Finally, the potential function of PRDM4 in HCC was explored. Conclusion This study comprehensively elucidated the indispensable role of m6A modification patterns in the complexity of TIME. The quantitative identification of m6A modification patterns in individual tumors will contribute to optimizing precision immunotherapy.
英文关键词	Hepatocellular carcinoma m6A modification patterns Tumor immune microenvironment Immunotherapy Tumor mutation burden PRDM4
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000841121700001
WOS关键词	CHECKPOINT BLOCKADE ; T-CELLS ; CANCER ; IMMUNOTHERAPY ; MACROPHAGES
WOS类目	Oncology
WOS研究方向	Oncology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/397206
推荐引用方式 GB/T 7714	Zhou, Dongkai,Wang, Yizhi,Wei, Wei,et al. m6A regulator-mediated methylation modification highlights immune infiltration patterns for predicting risk in hepatocellular carcinoma[J],2023,149(7):3661-3680.
APA	Zhou, Dongkai.,Wang, Yizhi.,Wei, Wei.,Zhou, Wei.,Gu, Jin.,...&Wu, Yingsheng.(2023).m6A regulator-mediated methylation modification highlights immune infiltration patterns for predicting risk in hepatocellular carcinoma.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,149(7),3661-3680.
MLA	Zhou, Dongkai,et al."m6A regulator-mediated methylation modification highlights immune infiltration patterns for predicting risk in hepatocellular carcinoma".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 149.7(2023):3661-3680.