干旱区生态环境知识资源中心(Arid): Salt-Tolerant Plants, Halophytes, as Renewable Natural Resources for Cancer Prevention and Treatment: Roles of Phenolics and Flavonoids in Immunomodulation and Suppression of Oxidative Stress towards Cancer Management

Arid

DOI	10.3390/ijms24065171
	Salt-Tolerant Plants, Halophytes, as Renewable Natural Resources for Cancer Prevention and Treatment: Roles of Phenolics and Flavonoids in Immunomodulation and Suppression of Oxidative Stress towards Cancer Management
	Mohammed, Hamdoon A.; Emwas, Abdul-Hamid; Khan, Riaz A.
通讯作者	Mohammed, HA ; Khan, RA
来源期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN	1661-6596
EISSN	1422-0067
出版年	2023
卷号	24 期号:6
英文摘要	Halophytes and xerophytes, plants with adequate tolerance to high salinity with strong ability to survive in drought ecosystem, have been recognized for their nutritional and medicinal values owing to their comparatively higher productions of secondary metabolites, primarily the phenolics, and the flavonoids, as compared to the normal vegetation in other climatic regions. Given the consistent increases in desertification around the world, which are associated with increasing salinity, high temperature, and water scarcity, the survival of halophytes due to their secondary metabolic contents has prioritized these plant species, which have now become increasingly important for environmental protection, land reclamation, and food and animal-feed security, with their primary utility in traditional societies as sources of drugs. On the medicinal herbs front, because the fight against cancer is still ongoing, there is an urgent need for development of more efficient, safe, and novel chemotherapeutic agents, than those currently available. The current review describes these plants and their secondary-metabolite-based chemical products as promising candidates for developing newer cancer therapeutics. It further discusses the prophylactic roles of these plants, and their constituents in prevention and management of cancers, through an exploration of their phytochemical and pharmacological properties, with a view on immunomodulation. The important roles of various phenolics and structurally diverse flavonoids as major constituents of the halophytes in suppressing oxidative stress, immunomodulation, and anti-cancer effects are the subject matter of this review and these aspects are outlined in details.
英文关键词	halophytes salt-tolerance secondary metabolites phenolics flavonoids oxidative stress immunomodulation oxidation anti-cancer activity cancer management
类型	Review
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000958449600001
WOS关键词	ARYL-HYDROCARBON RECEPTOR ; ANTICANCER ACTIVITIES ; MEDICINAL-PLANTS ; CELL-CYCLE ; MITOCHONDRIAL DYSFUNCTION ; INHIBITS PROLIFERATION ; ANTIOXIDANT ACTIVITIES ; TRADITIONAL MEDICINE ; MOLECULAR-MECHANISMS ; LIMONIUM-DENSIFLORUM
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/397015
推荐引用方式 GB/T 7714	Mohammed, Hamdoon A.,Emwas, Abdul-Hamid,Khan, Riaz A.. Salt-Tolerant Plants, Halophytes, as Renewable Natural Resources for Cancer Prevention and Treatment: Roles of Phenolics and Flavonoids in Immunomodulation and Suppression of Oxidative Stress towards Cancer Management[J],2023,24(6).
APA	Mohammed, Hamdoon A.,Emwas, Abdul-Hamid,&Khan, Riaz A..(2023).Salt-Tolerant Plants, Halophytes, as Renewable Natural Resources for Cancer Prevention and Treatment: Roles of Phenolics and Flavonoids in Immunomodulation and Suppression of Oxidative Stress towards Cancer Management.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(6).
MLA	Mohammed, Hamdoon A.,et al."Salt-Tolerant Plants, Halophytes, as Renewable Natural Resources for Cancer Prevention and Treatment: Roles of Phenolics and Flavonoids in Immunomodulation and Suppression of Oxidative Stress towards Cancer Management".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.6(2023).