干旱区生态环境知识资源中心(Arid): Relationships between hormone levels, metabolism and immune response in toads from a semi-arid region

Arid

DOI	10.1016/j.ygcen.2023.114263
	Relationships between hormone levels, metabolism and immune response in toads from a semi-arid region
	Madelaire, Carla B.; Gomes, Fernando R.
通讯作者	Madelaire, CB
来源期刊	GENERAL AND COMPARATIVE ENDOCRINOLOGY
ISSN	0016-6480
EISSN	1095-6840
出版年	2023
卷号	338
英文摘要	Steroid hormones (e.g. androgens [AN] and corticosterone [CORT]) modulate complex physiological functions such as reproduction, energy mobilization, metabolism, and immunity. The effects of these steroids on immunocompetence and its metabolic costs can also be affected by fluctuations in environmental resource availability and other factors such as parasitism. To understand these possible interactions, we studied AN and CORT, immune response [swelling response to phytohemagglutinin (PHA) injection and bacterial killing ability (BKA)], parasite load, resting metabolic rate (RMR) and post-immune challenge (PHA injection) oxygen consumption rates during two different phases of the annual cycle of Rhinella jimi toads from the Brazilian semi-arid region (Caatinga), where environmental conditions are highly seasonal. We observed an increase in O2 consumption rates after both PHA and saline (control) injections, indicating a metabolic response to adverse stimuli rather than the immune challenge. Toads showing higher RMR and VO2 after the adverse stimuli (PHA/saline injections) had lower field AN and CORT plasma levels, suggesting these hormones might mediate a metabolic energy conservation strategy both at baseline levels and after adverse stimuli. Parasite load appear to constrain the metabolic response to PHA and saline injections. Additionally, individuals with a higher swelling response to PHA had higher field CORT plasma levels (particularly when males are breeding), which opposes the idea of a possible trade-off between reproductive activity and other physiological traits, indicating the immunoenhancing effects of elevated CORT at physiological levels. BKA did not show a seasonal variation or correlation with body condition or hormone levels, indicating that the immune surveillance mediated by the complement remains constant despite ecological and physiological changes.
英文关键词	Testosterone Corticosterone Bacterial killing ability PHA Adverse stimuli Caatinga
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000979184700001
WOS关键词	IMMUNOCOMPETENCE HANDICAP HYPOTHESIS ; TRADE-OFFS ; LOCOMOTOR PERFORMANCE ; PARASITE INTENSITY ; PLASMA-LEVELS ; CORTICOSTERONE ; TESTOSTERONE ; STRESS ; HISTORY ; ENERGY
WOS类目	Endocrinology & Metabolism ; Zoology
WOS研究方向	Endocrinology & Metabolism ; Zoology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/396664
推荐引用方式 GB/T 7714	Madelaire, Carla B.,Gomes, Fernando R.. Relationships between hormone levels, metabolism and immune response in toads from a semi-arid region[J],2023,338.
APA	Madelaire, Carla B.,&Gomes, Fernando R..(2023).Relationships between hormone levels, metabolism and immune response in toads from a semi-arid region.GENERAL AND COMPARATIVE ENDOCRINOLOGY,338.
MLA	Madelaire, Carla B.,et al."Relationships between hormone levels, metabolism and immune response in toads from a semi-arid region".GENERAL AND COMPARATIVE ENDOCRINOLOGY 338(2023).