干旱区生态环境知识资源中心(Arid): Whole-brain structure-function coupling abnormalities in mild cognitive impairment: a study combining amplitude of low-frequency fluctuations and voxel-based morphometry

Arid

DOI	10.3389/fnins.2023.1236221
	Whole-brain structure-function coupling abnormalities in mild cognitive impairment: a study combining amplitude of low-frequency fluctuations and voxel-based morphometry
	Zhao, Rong; Wang, Pan; Liu, Lin; Zhang, Fanyu; Hu, Peng; Wen, Jiaping; Li, Hongyi; Biswal, Bharat B.
通讯作者	Wang, P ; Biswal, BB
来源期刊	FRONTIERS IN NEUROSCIENCE
EISSN	1662-453X
出版年	2023
卷号	17
英文摘要	Alzheimer's disease (AD), one of the leading diseases of the nervous system, is accompanied by symptoms such as loss of memory, thinking and language skills. Both mild cognitive impairment (MCI) and very mild cognitive impairment (VMCI) are the transitional pathological stages between normal aging and AD. While the changes in whole-brain structural and functional information have been extensively investigated in AD, The impaired structure-function coupling remains unknown. The current study employed the OASIS-3 dataset, which includes 53 MCI, 90 VMCI, and 100 Age-, gender-, and education-matched normal controls (NC). Several structural and functional parameters, such as the amplitude of low-frequency fluctuations (ALFF), voxel-based morphometry (VBM), and The ALFF/VBM ratio, were used To estimate The whole-brain neuroimaging changes In MCI, VMCI, and NC. As disease symptoms became more severe, these regions, distributed in the frontal-inf-orb, putamen, and paracentral lobule in the white matter (WM), exhibited progressively increasing ALFF (ALFF(NC) < ALFF(VMCI) < ALFF(MCI)), which was similar to the tendency for The cerebellum and putamen in the gray matter (GM). Additionally, as symptoms worsened in AD, the cuneus/frontal lobe in the WM and the parahippocampal gyrus/hippocampus in the GM showed progressively decreasing structure-function coupling. As the typical focal areas in AD, The parahippocampal gyrus and hippocampus showed significant positive correlations with the severity of cognitive impairment, suggesting the important applications of the ALFF/VBM ratio in brain disorders. On the other hand, these findings from WM functional signals provided a novel perspective for understanding the pathophysiological mechanisms involved In cognitive decline in AD.
英文关键词	Alzheimer's disease amplitude of low frequency fluctuations structure-function coupling voxel-based morphometry white matter
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:001047318800001
WOS关键词	ALZHEIMERS-DISEASE ; WHITE-MATTER ; EXECUTIVE FUNCTION ; PARAHIPPOCAMPAL GYRUS ; ORBITOFRONTAL CORTEX ; CORPUS-CALLOSUM ; CONNECTIVITY ; STATE ; NETWORKS ; DEMENTIA
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/396574
推荐引用方式 GB/T 7714	Zhao, Rong,Wang, Pan,Liu, Lin,et al. Whole-brain structure-function coupling abnormalities in mild cognitive impairment: a study combining amplitude of low-frequency fluctuations and voxel-based morphometry[J],2023,17.
APA	Zhao, Rong.,Wang, Pan.,Liu, Lin.,Zhang, Fanyu.,Hu, Peng.,...&Biswal, Bharat B..(2023).Whole-brain structure-function coupling abnormalities in mild cognitive impairment: a study combining amplitude of low-frequency fluctuations and voxel-based morphometry.FRONTIERS IN NEUROSCIENCE,17.
MLA	Zhao, Rong,et al."Whole-brain structure-function coupling abnormalities in mild cognitive impairment: a study combining amplitude of low-frequency fluctuations and voxel-based morphometry".FRONTIERS IN NEUROSCIENCE 17(2023).