干旱区生态环境知识资源中心(Arid): Apolipoprotein E ε4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment

Arid

DOI	10.3389/fnagi.2023.1158579
	Apolipoprotein E ε4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment
	Huang, Yuda; Shan, Yongzhi; Qin, Wen; Zhao, Guoguang
通讯作者	Shan, YZ ; Zhao, GG
来源期刊	FRONTIERS IN AGING NEUROSCIENCE
ISSN	1663-4365
出版年	2023
卷号	15
英文摘要	IntroductionEarly studies have reported that APOE is strongly associated with brain atrophy and cognitive decline among healthy elders and Alzheimer's disease (AD). However, previous research has not directly outlined the modulation of APOE on the trajectory of cerebral atrophy with aging during the conversion from cognitive normal (CN) to dementia (CN2D). MethodsThis study tried to elucidate this issue from a voxel-wise whole-brain perspective based on 416 qualified participants from a longitudinal OASIS-3 neuroimaging cohort. A voxel-wise linear mixed-effects model was applied for detecting cerebrum regions whose nonlinear atrophic trajectories were driven by AD conversion and to elucidate the effect of APOE variants on the cerebral atrophic trajectories during the process. ResultsWe found that CN2D participants had faster quadratically accelerated atrophy in bilateral hippocampi than persistent CN. Moreover, APOE epsilon 4 carriers had faster-accelerated atrophy in the left hippocampus than epsilon 4 noncarriers in both CN2D and persistent CN, and CN2D epsilon 4 carriers an noncarriers presented a faster atrophic speed than CN epsilon 4 carriers. These findings could be replicated in a sub-sample with a tough match in demographic information. DiscussionOur findings filled the gap that APOE epsilon 4 accelerates hippocampal atrophy and the conversion from normal cognition to dementia.
英文关键词	Alzheimer's disease cerebral atrophic apolipoprotein E aging dementia
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:001006377400001
WOS关键词	GENOME-WIDE ASSOCIATION ; GRAY-MATTER VOLUME ; ALZHEIMERS-DISEASE ; RISK LOCI ; HIPPOCAMPAL ATROPHY ; AMYLOID DEPOSITION ; APOE GENOTYPE ; A-BETA ; MEMORY ; MRI
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/396466
推荐引用方式 GB/T 7714	Huang, Yuda,Shan, Yongzhi,Qin, Wen,et al. Apolipoprotein E ε4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment[J],2023,15.
APA	Huang, Yuda,Shan, Yongzhi,Qin, Wen,&Zhao, Guoguang.(2023).Apolipoprotein E ε4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment.FRONTIERS IN AGING NEUROSCIENCE,15.
MLA	Huang, Yuda,et al."Apolipoprotein E ε4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment".FRONTIERS IN AGING NEUROSCIENCE 15(2023).