干旱区生态环境知识资源中心(Arid): Comparative metabolomics of the different fractions of two saltwort (Salsola L.) species in relation to their anti-inflammatory activity

Arid

DOI	10.1016/j.fbio.2022.102306
	Comparative metabolomics of the different fractions of two saltwort (Salsola L.) species in relation to their anti-inflammatory activity
	Selim, Dina A.; Shawky, Eman; Ghareeb, Doaa A.; Abdulmalek, Shaymaa A.; El-Khair, Rasha M. Abu
通讯作者	Shawky, E
来源期刊	FOOD BIOSCIENCE
ISSN	2212-4292
EISSN	2212-4306
出版年	2023
卷号	51
英文摘要	Many of the plants of genus Salsola are edible halophytes which are known for their use in treatment of inflammation as well as their nutritional content. This study aims at comprehensive chemical profiling of two Salsola species that are widely distributed in arid areas; S. imbricata and S. jordanicola, using UHPLC-QqQ-MS in an attempt to decipher the bioactive constituents of the aerial parts of the selected plants and their ex-vivo antiinflammatory activity. 73 chromatographic peaks were annotated where phytosterols dominated the metabolites in S. imbracta while phenylalkylamines were the major constituents detected in S. jordanicola. OPLS-DA model coefficients plot indicated that tetradecanoic acid, beta sitosterol and pentacosane were positively correlated to discrimination of S. imbricata species while N-feruloyloctopamine, N-feruloyltyramine, and ferulic acid, were positively correlated to discrimination of S. jordanicola species. Meanwhile, fractions of S. imbracta, reduced the 5 upregulation of TNF-alpha caused by LPS to levels lower than those produced by piroxicam while the petroleum ether and n-butanol fraction of S. jordanicola were more effective than piroxicam in reducing IL-6 gene expression. The coefficients plot depicted that methyl palmitate, aegicin, cleomiscoside, beta sitosterol and sitostanol possessed strong positive correlation to the down regulation of the pro-inflammatory marker TNF-alpha, IL-1 beta and IFN-gamma while only norepinephrine derivatives were the major metabolites that showed strong positive correlation to the inhibition of IL-6 pro-inflammatory marker. The results obtained may help to explain chemically, the potential anti-inflammatory effect of the various Salsola species fractions increasing the value of the Salsola species as a putative functional foods.
英文关键词	Salsola jordanicola Salsola imbricata Chemometrics Anti-inflammatory UPLC MS Metabolomics
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000912340000001
WOS关键词	TUMOR-NECROSIS-FACTOR ; PLANTS ; ACIDS
WOS类目	Food Science & Technology
WOS研究方向	Food Science & Technology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/396372
推荐引用方式 GB/T 7714	Selim, Dina A.,Shawky, Eman,Ghareeb, Doaa A.,et al. Comparative metabolomics of the different fractions of two saltwort (Salsola L.) species in relation to their anti-inflammatory activity[J],2023,51.
APA	Selim, Dina A.,Shawky, Eman,Ghareeb, Doaa A.,Abdulmalek, Shaymaa A.,&El-Khair, Rasha M. Abu.(2023).Comparative metabolomics of the different fractions of two saltwort (Salsola L.) species in relation to their anti-inflammatory activity.FOOD BIOSCIENCE,51.
MLA	Selim, Dina A.,et al."Comparative metabolomics of the different fractions of two saltwort (Salsola L.) species in relation to their anti-inflammatory activity".FOOD BIOSCIENCE 51(2023).