干旱区生态环境知识资源中心(Arid): Cordia oncocalyx and oncocalyxones: From the phytochemistry to the anticancer action and therapeutic benefits against chronic diseases

Arid

DOI	10.1016/j.fitote.2023.105624
	Cordia oncocalyx and oncocalyxones: From the phytochemistry to the anticancer action and therapeutic benefits against chronic diseases
	Ferreira, Paulo Michel Pinheiro; de Almeida, Antonia Amanda Cardoso; Conceicao, Micaely Lorrana Pereira; Pessoa, Otilia Deusdenia Loiola; Marques, Lana Grasiela Alves; Capasso, Raffaele; Pessoa, Claudia
通讯作者	Ferreira, PMP
来源期刊	FITOTERAPIA
ISSN	0367-326X
EISSN	1873-6971
出版年	2023
卷号	169
英文摘要	Cordia oncocalyx Allema & SIM;o is an endemic economically underexploited plant from Brazilian semi-arid region. Herein, we carried out a well-defined bibliographic review about the pharmacological activities of oncocalyxones from C. oncocalyx and mechanisms responsible for the biomedical properties. MeSH terms were used in the scientific databases for a narrative exploration. Technological development and bioproducts were also examined. Cordia oncocalyx is a deciduous tree of sexual reproduction rich in terpenoid quinones. Among them, oncocalyxone A, a 1,4-benzoquinone, the main compound from heartwood ethanol extracts, revealed anti-inflammatory and anti-edematogenic actions induced by carrageenan and dextran and antinociceptive potential in mice provoked by acetic acid and formalin. Oncocalyxone A inhibits platelet aggregation via activation of the soluble guanylate cyclase enzyme and blocks glycation processes. In addition to the antimicrobial effects against protozoa, fungi and bacteria and relaxation of smooth muscles, oncocalyxone A reduces mean blood pressure and glycemia in diabetic rats, decreases glomerular filtration parameters and tubular transport of electrolytes, and presents in vitro antimitotic and cytotoxic action upon different types of cancers, including resistant lung carcinoma lines. It has low oral acute toxicity (LD50 > 2000 mg/kg) and activates cellular apoptosis through the production of free radicals and interactions with DNA. However, no patents were found, which also emphasizes that Brazil, as the cradle of the main articles on C. oncocalyx, is wasting time and money. Moreover, slight systemic deleterious effects in mammals stimulate the use of oncocalyxone A and related compounds as lead constituents of safer drugs against chronic diseases.
英文关键词	Antitumoral action Anti-inflammatory Aspirin -like effects Benzoquinone Cordia oncocalyx Patent mapping
类型	Review
语种	英语
收录类别	SCI-E
WOS记录号	WOS:001059519400001
WOS关键词	AUXEMMA-ONCOCALYX ; IN-VITRO ; MEDICINAL-PLANTS ; QUINONE FRACTION ; DERIVATIVES ; INHIBITION ; RECEPTORS ; VIVO ; J78
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/396365
推荐引用方式 GB/T 7714	Ferreira, Paulo Michel Pinheiro,de Almeida, Antonia Amanda Cardoso,Conceicao, Micaely Lorrana Pereira,et al. Cordia oncocalyx and oncocalyxones: From the phytochemistry to the anticancer action and therapeutic benefits against chronic diseases[J],2023,169.
APA	Ferreira, Paulo Michel Pinheiro.,de Almeida, Antonia Amanda Cardoso.,Conceicao, Micaely Lorrana Pereira.,Pessoa, Otilia Deusdenia Loiola.,Marques, Lana Grasiela Alves.,...&Pessoa, Claudia.(2023).Cordia oncocalyx and oncocalyxones: From the phytochemistry to the anticancer action and therapeutic benefits against chronic diseases.FITOTERAPIA,169.
MLA	Ferreira, Paulo Michel Pinheiro,et al."Cordia oncocalyx and oncocalyxones: From the phytochemistry to the anticancer action and therapeutic benefits against chronic diseases".FITOTERAPIA 169(2023).