干旱区生态环境知识资源中心(Arid): East asian herbal medicine for the treatment of children with attention deficit hyperactivity disorder: A Systematic Review and Meta-analysis

Arid

DOI	10.1016/j.explore.2022.11.002
	East asian herbal medicine for the treatment of children with attention deficit hyperactivity disorder: A Systematic Review and Meta-analysis
	Lee, Ju Hyun; Jo, Hee Geun; Min, Sang Yeon
通讯作者	Jo, HG
来源期刊	EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
ISSN	1550-8307
EISSN	1878-7541
出版年	2023
卷号	19 期号:3 页码:330-355
英文摘要	Background: Attention deficit hyperactivity disorder (ADHD) is a mental illness that can place a significant burden on individuals, their families, and society. East Asian Herbal Medicine (EAHM) has long been used in East Asian nations to treat mental illness in children. Nevertheless, the evidence for the effectiveness of EAHM for the treatment of ADHD is insufficient. A systematic review was performed to examine the effectiveness and safety. In addition, research on core herbal combinations was also conducted to help clinicians in their prescription selection.Materials and methods: This systematic review and meta-analysis were prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The following databases were searched: 4 English databases (PubMed, Cochrane Library, Cumulative Index to Nursing & Allied Health Literature (CINAHL), EMBASE), 4 Korean databases (Korean Studies Information Service System (KISS), Research Infor-mation Service System (RISS), Oriental Medicine Advanced Searching Integrated System (OASIS), Korea Citation Index (KCI)), 2 Chinese databases (Chinese National Knowledge Infrastructure Database (CNKI), Wanfang Data), and 1 Japanese database (CiNii) database. The publication bias was evaluated using funnel plots. GRADE pro was used to evaluate the evidence of the study. The core herb combination of EAHM used in this study was revealed using apriori algorithm-based association rule mining.Results: This review assessed 42 studies that evaluated 3484 children and adolescents. In meta-analysis, EAHM monotherapy had a similar clinical efficacy rate to conventional medicine (CM) (n = 2166; random effects RR 1.09, 95% CI 1.05 to 1.13; heterogeneity chi 2= 25.08, df = 23, p = 0.35, I2=8%). EAHM-combined therapy showed a better clinical efficacy rate than when conventional therapy was used alone (n = 746; fixed effects RR 1.19, 95% CI 1.12 to 1.26; heterogeneity chi 2= 11.80, df = 9, p = 0.22, I2=24%). For adverse events, EAHM had a lower incidence than conventional therapy. In GRADE pro, each outcome varied from moderate to very low quality. The constituents of the herb combinations with consistent association rules were Fossilia Ossis Mastodi, Polygalae Radix, and Acori Graminei Rhizoma. Conclusion: EAHM monotherapy has similar effects to CM but with fewer side effects. Hence, it will be helpful for children with ADHD suffering from the side effects of CM. EAHM-combined therapy has a better effect than con-ventional therapy. Accordingly, it will be useful for children with ADHD who do not respond to treatment with conventional therapy. Nevertheless, more well-designed studies will be needed to confirm this in the future.
英文关键词	East asian herbal medicine Attention deficit hyperactivity disorder Randomized controlled trial Systematic review Meta-analysis Association rule
类型	Review
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000984529000001
WOS关键词	ADHD ; RHIZOMA
WOS类目	Integrative & Complementary Medicine
WOS研究方向	Integrative & Complementary Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/396346
推荐引用方式 GB/T 7714	Lee, Ju Hyun,Jo, Hee Geun,Min, Sang Yeon. East asian herbal medicine for the treatment of children with attention deficit hyperactivity disorder: A Systematic Review and Meta-analysis[J],2023,19(3):330-355.
APA	Lee, Ju Hyun,Jo, Hee Geun,&Min, Sang Yeon.(2023).East asian herbal medicine for the treatment of children with attention deficit hyperactivity disorder: A Systematic Review and Meta-analysis.EXPLORE-THE JOURNAL OF SCIENCE AND HEALING,19(3),330-355.
MLA	Lee, Ju Hyun,et al."East asian herbal medicine for the treatment of children with attention deficit hyperactivity disorder: A Systematic Review and Meta-analysis".EXPLORE-THE JOURNAL OF SCIENCE AND HEALING 19.3(2023):330-355.