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DOI	10.1002/dta.3392
	Optimization, validation and application of a high-throughput 96-well elution protocol for the quantification of psychoactive substances in influent wastewater
	Boogaerts, Tim; Quireyns, Maarten; Maes, Florence; Laimou-Geraniou, Maria; Van Wichelen, Natan; Heath, Ester; Pussig, Bram; Aertgeerts, Bert; Covaci, Adrian; van Nuijs, Alexander L. N.
通讯作者	Boogaerts, T
来源期刊	DRUG TESTING AND ANALYSIS
ISSN	1942-7603
EISSN	1942-7611
出版年	2023
卷号	15 期号:2 页码:240-246
英文摘要	Wastewater-based epidemiology (WBE) is based on the analysis of human metabolic excretion products (biomarkers) of xenobiotics in wastewater, to gain information about various lifestyles and health aspects of a population in an evidence-based manner. Due to the complex wastewater matrix and trace level occurrence of human biomarkers in the sewage network, it is crucial to have sensitive analytical procedures available. Additionally, to improve the value of WBE as a complementary epidemiological source, there is increasing pressure on the analysis of more compounds, more locations and more samples. A high-throughput method based on 96-well Oasis MCX solid-phase extraction (SPE), requiring less influent wastewater (2 mL), was developed in accordance with the European Medicines Agency guidelines. Validation was successful for 28 parent drugs and metabolites of antidepressants, opioids and drugs of abuse. The selection of biomarkers and quantification limit was chosen to be relevant for WBE and was predominantly 10 ng/L or below. The final method was successfully applied to 24-h composite samples of October 2019 (n = 27), obtained from an urban wastewater treatment plant in Leuven (Belgium).
英文关键词	96-well solid-phase extraction high-throughput analysis psychoactive substances wastewater-based epidemiology
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000879963500001
WOS关键词	BIOMARKERS ; ABUSE
WOS类目	Biochemical Research Methods ; Chemistry, Analytical ; Pharmacology & Pharmacy
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/395868
推荐引用方式 GB/T 7714	Boogaerts, Tim,Quireyns, Maarten,Maes, Florence,et al. Optimization, validation and application of a high-throughput 96-well elution protocol for the quantification of psychoactive substances in influent wastewater[J],2023,15(2):240-246.
APA	Boogaerts, Tim.,Quireyns, Maarten.,Maes, Florence.,Laimou-Geraniou, Maria.,Van Wichelen, Natan.,...&van Nuijs, Alexander L. N..(2023).Optimization, validation and application of a high-throughput 96-well elution protocol for the quantification of psychoactive substances in influent wastewater.DRUG TESTING AND ANALYSIS,15(2),240-246.
MLA	Boogaerts, Tim,et al."Optimization, validation and application of a high-throughput 96-well elution protocol for the quantification of psychoactive substances in influent wastewater".DRUG TESTING AND ANALYSIS 15.2(2023):240-246.