干旱区生态环境知识资源中心(Arid): The first fully optimized and validated SPE-LC-MS/MS method for determination of the new-generation neonicotinoids in surface water samples

Arid

DOI	10.1016/j.chemosphere.2022.136868
	The first fully optimized and validated SPE-LC-MS/MS method for determination of the new-generation neonicotinoids in surface water samples
	Lukaszewicz, Paulina; Stepnowski, Piotr; Halinski, Lukasz P.
通讯作者	Lukaszewicz, P
来源期刊	CHEMOSPHERE
ISSN	0045-6535
EISSN	1879-1298
出版年	2023
卷号	310
英文摘要	Widespread use of the new generation neonicotinoids (NQs) results in their constant inflow to water bodies. Both their persistence in waters and mechanism of action similar to older compounds already banned in the EU raise concerns about potential ecotoxicological effects. Information about presence of the new NQs in the aquatic environment is still sparse, and the consequences for aquatic organisms remain mostly unknown, due to the lack of sensitive and selective analytical tools. Therefore, a method utilizing solid-phase extraction and liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) has been developed and optimized, enabling the monitoring of EU-approved NQs: acetamiprid (ACT), sulfoxaflor (SFX) and flupyradifurone (FLU), and common NQ metabolite 6-chloronicotinoic acid (6-CNA) in surface waters. To optimize their extraction from natural water samples, the response surface methodology (RSM) was used. An increase in pH value favored higher absolute recoveries (AR) of ACT, SFX and FLU, while the opposite effect was observed for 6-CNA. Increasing water sample volume had adverse effect on the extraction of all compounds. The optimal conditions for simultaneous extraction of all compounds included the use of Oasis HLB sorbent, 200 mL of a water sample at pH of 4.6, and application of 0.3% HCOOH in acetonitrile as an eluent, allowing to obtain AR values above 80% in most cases. Further increase in pH value had positive impact on extraction effectiveness of ACT, SFX and FLU. The method was subjected to full matrix-matched validation and was proven to be fully reliable for the analysis of ACT, SFX and FLU, while the successful isolation of 6-CNA depends on the matrix composition. Finally, the method was applied to the analysis of NQs in surface water samples, proving its sensitivity and selectivity. It can be easily adapted as a tool for trace analysis of NQs and for NQ-associated risk assessment in aquatic ecosystems.
英文关键词	Surface waters Neonicotinoids Response surface methodology Solid phase extraction LC-MS MS
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000913389300007
WOS关键词	ENVIRONMENTAL RISKS ; INSECTICIDES ; SULFOXAFLOR ; CHROMATOGRAPHY ; METABOLITES ; TOXICITY ; FATE ; SOIL
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/395739
推荐引用方式 GB/T 7714	Lukaszewicz, Paulina,Stepnowski, Piotr,Halinski, Lukasz P.. The first fully optimized and validated SPE-LC-MS/MS method for determination of the new-generation neonicotinoids in surface water samples[J],2023,310.
APA	Lukaszewicz, Paulina,Stepnowski, Piotr,&Halinski, Lukasz P..(2023).The first fully optimized and validated SPE-LC-MS/MS method for determination of the new-generation neonicotinoids in surface water samples.CHEMOSPHERE,310.
MLA	Lukaszewicz, Paulina,et al."The first fully optimized and validated SPE-LC-MS/MS method for determination of the new-generation neonicotinoids in surface water samples".CHEMOSPHERE 310(2023).