干旱区生态环境知识资源中心(Arid): p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS

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DOI	10.1016/j.celrep.2023.112479
	p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
	Saito, Atsushi; Kamikawa, Yasunao; Ito, Taichi; Matsuhisa, Koji; Kaneko, Masayuki; Okamoto, Takumi; Yoshimaru, Tetsuro; Matsushita, Yosuke; Katagiri, Toyomasa; Imaizumi, Kazunori
通讯作者	Saito, A ; Imaizumi, K
来源期刊	CELL REPORTS
ISSN	2211-1247
出版年	2023
卷号	42 期号:5
英文摘要	CREB/ATF transcription factor OASIS/CREB3L1 is upregulated in long-term-cultured astrocytes undergoing cell-cycle arrest due to loss of DNA integrity by repeated replication. However, the roles of OASIS in the cell cycle remain unexplored. We find that OASIS arrests the cell cycle at G2/M phase after DNA damage via direct induction of p21. Cell-cycle arrest by OASIS is dominant in astrocytes and osteoblasts, but not in fibroblasts, which are dependent on p53. In a brain injury model, Oasis-/- reactive astrocytes surrounding the lesion core show sustained growth and inhibition of cell-cycle arrest, resulting in prolonged gliosis. We find that some glioma patients exhibit low expression of OASIS due to high methylation of its promoter. Specific removal of this hypermethylation in glioblastomas transplanted into nude mice by epigenomic engineering sup-presses the tumorigenesis. These findings suggest OASIS as a critical cell-cycle inhibitor with potential to act as a tumor suppressor.
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:001012579500001
WOS关键词	CANCER ; GENE ; P53 ; PROLIFERATION ; EXPRESSION ; PLATFORM ; GROWTH ; IDH1 ; RESISTANCE
WOS类目	Cell Biology
WOS研究方向	Cell Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/395718
推荐引用方式 GB/T 7714	Saito, Atsushi,Kamikawa, Yasunao,Ito, Taichi,et al. p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS[J],2023,42(5).
APA	Saito, Atsushi.,Kamikawa, Yasunao.,Ito, Taichi.,Matsuhisa, Koji.,Kaneko, Masayuki.,...&Imaizumi, Kazunori.(2023).p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS.CELL REPORTS,42(5).
MLA	Saito, Atsushi,et al."p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS".CELL REPORTS 42.5(2023).