干旱区生态环境知识资源中心(Arid): Patient characteristics, validity of clinical diagnoses and Outcomes Associated with Suicidality in Inpatients with Symptoms of Depression (OASIS-D): design, procedures and outcomes

Arid

DOI	10.1186/s12888-023-05230-9
	Patient characteristics, validity of clinical diagnoses and Outcomes Associated with Suicidality in Inpatients with Symptoms of Depression (OASIS-D): design, procedures and outcomes
	Noehles, Viktor B.; Bermpohl, Felix; Falkai, Peter; Reif-Leonhard, Christine; Jessen, Frank; Adli, Mazda; Otte, Christian; Meyer-Lindenberg, Andreas; Bauer, Michael; Rubarth, Kerstin; Anghelescu, Ion-George; Rujescu, Dan; Correll, Christoph U.
通讯作者	Correll, CU
来源期刊	BMC PSYCHIATRY
EISSN	1471-244X
出版年	2023
卷号	23 期号:1
英文摘要	BackgroundSuicidality, ranging from passive suicidal thoughts to suicide attempt, is common in major depressive disorder (MDD). However, relatively little is known about patient, illness and treatment characteristics in those with co-occurring MDD and suicidality, including the timing of and factors associated with the offset, continuation or reemergence of suicidality. Here, we present the background, rationale, design and hypotheses of the Patient Characteristics, Validity of Clinical Diagnoses and Outcomes Associated with Suicidality in Inpatients with Symptoms of Depression (OASIS-D) study, an investigator-initiated, observational study, funded by Janssen-Cilag GmbH.Methods/ResultsOASIS-D is an eight-site, six-month, cohort study of patients aged 18-75 hospitalized with MDD. Divided into three sub-studies and patient populations (PPs), OASIS-D will (i) systematically characterize approximately 4500 consecutively hospitalized patients with any form of unipolar depressive episode (PP1), (ii) evaluate the validity of the clinical diagnosis of moderate or severe unipolar depressive episode with the Mini-International Neuropsychiatric Interview (M.I.N.I.) and present suicidality (at least passive suicidal thoughts) present >= 48 h after admission with the Sheehan-Suicide Tracking Scale (S-STS), assessing also predictors of the diagnostic concordance/discordance of MDD in around 500 inpatients (PP2), and (iii) characterize and prospectively follow for 6 months 315 inpatients with a research-verified moderate or severe unipolar depressive episode and at least passive suicidal thoughts >= 48 h after admission, evaluating treatment and illness/response patterns at baseline, hospital discharge, 3 and 6 months. Exploratory objectives will describe the association between the number of days with suicidality and utilization of outpatient and inpatient care services, and structured assessments of factors influencing the risk of self-injurious behavior without suicidal intent, and of continuous, intermittent or remitted suicidality during the 6-month observation period.ConclusionDespite their frequency and clinical relevance, relatively little is known about patient and treatment characteristics of individuals with MDD and suicidality, including factors moderating and mediating the outcome of both MDD and suicidality. Results of the OASIS-D study are hoped to improve the understanding of the frequency, correlates and 6-month naturalistic treatment and outcome trajectories of different levels of suicidality in hospitalized adults with MDD and suicidality.Trial registrationNCT04404309 [ClinicalTrials.gov]
英文关键词	Depression Suicidality Observational study Treatment Correlates Diagnostic agreement Moderators Mediators
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:001087398300001
WOS关键词	ESKETAMINE NASAL SPRAY ; TREATMENT-RESISTANT DEPRESSION ; MEASUREMENT-BASED CARE ; MAJOR DEPRESSION ; RISK-FACTORS ; DSM-IV ; PSYCHOMETRIC EVALUATION ; ANXIOUS DEPRESSION ; TREATMENT PATTERNS ; CANADIAN NETWORK
WOS类目	Psychiatry
WOS研究方向	Psychiatry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/395596
推荐引用方式 GB/T 7714	Noehles, Viktor B.,Bermpohl, Felix,Falkai, Peter,et al. Patient characteristics, validity of clinical diagnoses and Outcomes Associated with Suicidality in Inpatients with Symptoms of Depression (OASIS-D): design, procedures and outcomes[J],2023,23(1).
APA	Noehles, Viktor B..,Bermpohl, Felix.,Falkai, Peter.,Reif-Leonhard, Christine.,Jessen, Frank.,...&Correll, Christoph U..(2023).Patient characteristics, validity of clinical diagnoses and Outcomes Associated with Suicidality in Inpatients with Symptoms of Depression (OASIS-D): design, procedures and outcomes.BMC PSYCHIATRY,23(1).
MLA	Noehles, Viktor B.,et al."Patient characteristics, validity of clinical diagnoses and Outcomes Associated with Suicidality in Inpatients with Symptoms of Depression (OASIS-D): design, procedures and outcomes".BMC PSYCHIATRY 23.1(2023).