干旱区生态环境知识资源中心(Arid): Whole-genome sequencing reveals adaptations of hairy-footed jerboas (Dipus, Dipodidae) to diverse desert environments

Arid

DOI	10.1186/s12915-023-01680-5
	Whole-genome sequencing reveals adaptations of hairy-footed jerboas (Dipus, Dipodidae) to diverse desert environments
	Peng, Xingwen; Cheng, Jilong; Li, Hong; Feijo, Anderson; Xia, Lin; Ge, Deyan; Wen, Zhixin; Yang, Qisen
通讯作者	Yang, QS
来源期刊	BMC BIOLOGY
EISSN	1741-7007
出版年	2023
卷号	21 期号:1
英文摘要	Background Environmental conditions vary among deserts across the world, spanning from hyper-arid to high-elevation deserts. However, prior genomic studies on desert adaptation have focused on desert and non-desert comparisons overlooking the complexity of conditions within deserts. Focusing on the adaptation mechanisms to diverse desert environments will advance our understanding of how species adapt to extreme desert environments. The hairy-footed jerboas are well adapted to diverse desert environments, inhabiting high-altitude arid regions, hyper-arid deserts, and semi-deserts, but the genetic basis of their adaptation to different deserts remains unknown. Results Here, we sequenced the whole genome of 83 hairy-footed jerboas from distinct desert zones in China to assess how they responded under contrasting conditions. Population genomics analyses reveal the existence of three species in hairy-footed jerboas distributed in China: Dipus deasyi, Dipus sagitta, and Dipus sowerbyi. Analyses of selection between high-altitude desert (elevation >= 3000m) and low-altitude desert (< 500m) populations identified two strongly selected genes, ATR and HIF1AN, associated with intense UV radiation and hypoxia in high-altitude environments. A number of candidate genes involved in energy and water homeostasis were detected in the comparative genomic analyses of hyper-arid desert (average annual precipitation < 70mm) and arid desert (< 200mm) populations versus semi-desert (> 360mm) populations. Hyper-arid desert animals also exhibited stronger adaptive selection in energy homeostasis, suggesting water and resource scarcity may be the main drivers of desert adaptation in hairy-footed jerboas. Conclusions Our study challenges the view of deserts as homogeneous environments and shows that distinct genomic adaptations can be found among desert animals depending on their habitats.
英文关键词	Dipus High-altitude adaptation Hyper-arid adaptation Energy homeostasis Water balance Population genomics
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:001058604000001
WOS关键词	HIGH-ALTITUDE ADAPTATION ; SUBSPECIFIC DIFFERENTIATION ; GEOGRAPHICAL VARIATION ; MOLECULAR MECHANISMS ; DEMOGRAPHIC HISTORY ; PROTEIN CATABOLISM ; NATURAL-SELECTION ; SAGITTA RODENTIA ; GENETIC-BASIS ; P53 PATHWAY
WOS类目	Biology
WOS研究方向	Life Sciences & Biomedicine - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/395581
推荐引用方式 GB/T 7714	Peng, Xingwen,Cheng, Jilong,Li, Hong,et al. Whole-genome sequencing reveals adaptations of hairy-footed jerboas (Dipus, Dipodidae) to diverse desert environments[J],2023,21(1).
APA	Peng, Xingwen.,Cheng, Jilong.,Li, Hong.,Feijo, Anderson.,Xia, Lin.,...&Yang, Qisen.(2023).Whole-genome sequencing reveals adaptations of hairy-footed jerboas (Dipus, Dipodidae) to diverse desert environments.BMC BIOLOGY,21(1).
MLA	Peng, Xingwen,et al."Whole-genome sequencing reveals adaptations of hairy-footed jerboas (Dipus, Dipodidae) to diverse desert environments".BMC BIOLOGY 21.1(2023).