干旱区生态环境知识资源中心(Arid): Regulatory mechanisms of the cAMP-responsive element binding protein 3 (CREB3) family in cancers

Arid

DOI	10.1016/j.biopha.2023.115335
	Regulatory mechanisms of the cAMP-responsive element binding protein 3 (CREB3) family in cancers
	Yuxiong, Wang; Faping, Li; Bin, Liu; Yanghe, Zhang; Yao, Li; Yunkuo, Li; Yishu, Wang; Honglan, Zhou
通讯作者	Honglan, Z
来源期刊	BIOMEDICINE & PHARMACOTHERAPY
ISSN	0753-3322
EISSN	1950-6007
出版年	2023
卷号	166
英文摘要	The CREB3 family of proteins, encompassing CREB3 and its four homologs (CREB3L1, CREB3L2, CREB3L3, and CREB3L4), exerts pivotal control over cellular protein metabolism in response to unfolded protein reactions. Under conditions of endoplasmic reticulum stress, activation of the CREB3 family occurs through regulated intramembrane proteolysis within the endoplasmic reticulum membrane. Perturbations in the function and expression of the CREB3 family have been closely associated with the development of diverse diseases, with a particular emphasis on cancer. Recent investigations have shed light on the indispensable role played by CREB3 family members in modulating the onset and progression of various human cancers. This comprehensive review endeavors to provide an in-depth examination of the involvement of CREB3 family members in distinct human cancer types, accentuating their significance in the pathogenesis of cancer and the manifestation of malignant phenotypes.
英文关键词	CREB3 family Carcinogenesis Protein metabolism Unfolded protein response Endoplasmic reticulum stress Malignant phenotypes
类型	Review
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:001061618800001
WOS关键词	ENDOPLASMIC-RETICULUM STRESS ; SCLEROSING EPITHELIOID FIBROSARCOMA ; BOUND TRANSCRIPTION FACTOR ; GRADE FIBROMYXOID SARCOMA ; CREB/ATF FAMILY ; HUMAN LZIP ; SECRETORY PATHWAY ; TRANSDUCER OASIS ; GENE FUSION ; EXPRESSION
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/395573
推荐引用方式 GB/T 7714	Yuxiong, Wang,Faping, Li,Bin, Liu,et al. Regulatory mechanisms of the cAMP-responsive element binding protein 3 (CREB3) family in cancers[J],2023,166.
APA	Yuxiong, Wang.,Faping, Li.,Bin, Liu.,Yanghe, Zhang.,Yao, Li.,...&Honglan, Zhou.(2023).Regulatory mechanisms of the cAMP-responsive element binding protein 3 (CREB3) family in cancers.BIOMEDICINE & PHARMACOTHERAPY,166.
MLA	Yuxiong, Wang,et al."Regulatory mechanisms of the cAMP-responsive element binding protein 3 (CREB3) family in cancers".BIOMEDICINE & PHARMACOTHERAPY 166(2023).