干旱区生态环境知识资源中心(Arid): Simultaneous determination of macrolides in water samples by solid-phase extraction and capillary electrophoresis

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DOI	10.2478/acph-2023-0041
	Simultaneous determination of macrolides in water samples by solid-phase extraction and capillary electrophoresis
	Pavlovic, Dragana Mutavdzic; Babic, Sandra; Cizmic, Mirta; Sertic, Miranda; Pinusic, Tea
通讯作者	Pavlovic, DM
来源期刊	ACTA PHARMACEUTICA
ISSN	1330-0075
EISSN	1846-9558
出版年	2023
卷号	73 期号:4 页码:515-535
英文摘要	Solid-phase extraction (SPE) coupled with capillary electrophoresis (CE) for the determination of macrolide antibiotics (azithromycin, clarithromycin, roxithromycin, tylosin) and tiamulin in water samples was described in this article. These compounds were extracted with different types of sorbents ( Oasis HLB, C18, C8, SDB, and Strata-X) and different masses of sorbents (60 mg, 200 mg, and 500 mg) using different organic solvents (methanol, ethanol, and acetonitrile) and different pH values of water samples (pH 7.00, 8.00, and 9.00). It was found that the highest extraction efficiency of the studied compounds was obtained with 200 mg/3 mL C18 cartridges with methanol as eluent at pH 9.00 of the water sample. The developed SPE-CE method for macrolide antibiotics and tiamulin was validated for linearity, precision, repeatability, the limit of detection (LOD), the limit of quantification (LOQ), and recovery. Good linearity was obtained in the range of 0.3-30 mg L-1 depending on the drug, with correlation coefficients higher than 0.9958 in all cases except clarithromycin (0.9873). Expanded measurement uncertainties were calculated for each pharmaceutical, accounting for 20.31 % (azithromycin), 38.33 % (tiamulin), 28.95 % (clarithromycin), 26.99 % (roxithromycin), and 21.09 % (tiamulin). Uncertainties associated with precision and calibration curves contributed the most to the combined measurement uncertainty. The method was successfully applied to the analysis of production waste-water from the pharmaceutical industry.
英文关键词	macrolides tiamulin solid-phase extraction capillary electrophoresis wastewater measurement uncertainty
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:001133120100002
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; TANDEM MASS-SPECTROMETRY ; URBAN WASTE-WATER ; PHARMACEUTICALS ; ANTIBIOTICS ; ERYTHROMYCIN ; ENVIRONMENT ; RESIDUES ; FATE ; FOOD
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/394965
推荐引用方式 GB/T 7714	Pavlovic, Dragana Mutavdzic,Babic, Sandra,Cizmic, Mirta,et al. Simultaneous determination of macrolides in water samples by solid-phase extraction and capillary electrophoresis[J],2023,73(4):515-535.
APA	Pavlovic, Dragana Mutavdzic,Babic, Sandra,Cizmic, Mirta,Sertic, Miranda,&Pinusic, Tea.(2023).Simultaneous determination of macrolides in water samples by solid-phase extraction and capillary electrophoresis.ACTA PHARMACEUTICA,73(4),515-535.
MLA	Pavlovic, Dragana Mutavdzic,et al."Simultaneous determination of macrolides in water samples by solid-phase extraction and capillary electrophoresis".ACTA PHARMACEUTICA 73.4(2023):515-535.