Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.3390/toxins14070460 |
| Anticancer Activity of Bee Venom Components against Breast Cancer | |
| Kwon, Na-Yoen; Sung, Soo-Hyun; Sung, Hyun-Kyung; Park, Jang-Kyung | |
| 通讯作者 | Sung, HK |
| 来源期刊 | TOXINS
 |
| EISSN | 2072-6651 |
| 出版年 | 2022 |
| 卷号 | 14期号:7 |
| 英文摘要 | While the survival rate has increased due to treatments for breast cancer, the quality of life has decreased because of the side effects of chemotherapy. Various toxins are being developed as alternative breast cancer treatments, and bee venom is drawing attention as one of them. We analyzed the effect of bee venom and its components on breast cancer cells and reviewed the mechanism underlying the anticancer effects of bee venom. Data up to March 2022 were searched from PubMed, EMBASE, OASIS, KISS, and Science Direct online databases, and studies that met the inclusion criteria were reviewed. Among 612 studies, 11 were selected for this research. Diverse drugs were administered, including crude bee venom, melittin, phospholipase A2, and their complexes. All drugs reduced the number of breast cancer cells in proportion to the dose and time. The mechanisms of anticancer effects included cytotoxicity, apoptosis, cell targeting, gene expression regulation, and cell lysis. Summarily, bee venom and its components exert anticancer effects on human breast cancer cells. Depending on the mechanisms of anticancer effects, side effects are expected to be reduced by using various vehicles. Bee venom and its components have the potential to prevent and treat breast cancer in the future. |
| 英文关键词 | bee venom melittin phospholipase A2 breast cancer |
| 类型 | Review |
| 语种 | 英语 |
| 开放获取类型 | Green Published, gold |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000833728900001 |
| WOS关键词 | CULTURE-SYSTEMS ; ACTIVATION ; MELITTIN ; DELIVERY ; CELLS |
| WOS类目 | Food Science & Technology ; Toxicology |
| WOS研究方向 | Food Science & Technology ; Toxicology |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/394732 |
| 推荐引用方式 GB/T 7714 | Kwon, Na-Yoen,Sung, Soo-Hyun,Sung, Hyun-Kyung,et al. Anticancer Activity of Bee Venom Components against Breast Cancer[J],2022,14(7). |
| APA | Kwon, Na-Yoen,Sung, Soo-Hyun,Sung, Hyun-Kyung,&Park, Jang-Kyung.(2022).Anticancer Activity of Bee Venom Components against Breast Cancer.TOXINS,14(7). |
| MLA | Kwon, Na-Yoen,et al."Anticancer Activity of Bee Venom Components against Breast Cancer".TOXINS 14.7(2022). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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