干旱区生态环境知识资源中心(Arid): Simultaneous Extraction of Four Antibiotic Compounds from Soil and Water Matrices

Arid

DOI	10.3390/separations9080200
	Simultaneous Extraction of Four Antibiotic Compounds from Soil and Water Matrices
	Franklin, Alison M.; Andrews, Danielle M.; Williams, Clinton F.; Watson, John E.
通讯作者	Franklin, AM
来源期刊	SEPARATIONS
EISSN	2297-8739
出版年	2022
卷号	9 期号:8
英文摘要	The incidence of antibiotic resistance is on the rise and becoming a major health concern. Analyzing the presence of antibiotic compounds in the environment is critical for determining the potential health effects for humans, animals, and ecosystems. For this study, methods were developed to simultaneously isolate and quantify four antibiotics important in human medicine (sulfamethoxazole-SMX, trimethoprim-TMP, lincomycin-LIN, and ofloxacin-OFL) in water and soil matrices. For water analysis, different solid phase extraction (SPE) cartridges (Oasis HLB plus and Phenomenex Strata-X) were compared. The Oasis HLB Plus SPE cartridge provided the highest and most consistent recoveries with 118 +/- 5%, 86 +/- 4%, 83 +/- 5%, and 75 +/- 1% for SMX, TMP, LIN, and OFL, respectively. For soil analysis, different pre-treatments (grinding and freeze-drying) and soil extraction methodologies (liquid-solid extraction and accelerated solvent extraction (ASE)) were compared. The ASE system resulted in the highest overall recoveries of SMX, TMP, LIN, and OFL with an optimal extracting solution of acetonitrile/water (v/v, 50:50, pH 2.8). When the soil was ground and freeze-dried, trimethoprim recovery increased and when soil was ground, but not freeze-dried, LIN and OFL recoveries increased, while sulfamethoxazole recoveries decreased when soil was ground and freeze-dried. Based on this research, matrix characteristics, especially pH, as well as the pKa's and functional groups of the antibiotics need to be carefully considered when attempting to extract antibiotic compounds from a water or soil environment.
英文关键词	antibiotics sulfamethoxazole trimethoprim lincomycin ofloxacin soil water extraction solid phase extraction liquid-solid extraction accelerated solvent extraction liquid chromatography freeze-drying
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000845200600001
WOS关键词	FLUOROQUINOLONE ANTIBACTERIAL AGENTS ; PRESSURIZED LIQUID EXTRACTION ; WASTE-WATER ; CHROMATOGRAPHY ; PHARMACEUTICALS ; SORPTION ; LINCOMYCIN ; RESIDUES ; TRIMETHOPRIM ; METABOLITES
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/394493
推荐引用方式 GB/T 7714	Franklin, Alison M.,Andrews, Danielle M.,Williams, Clinton F.,et al. Simultaneous Extraction of Four Antibiotic Compounds from Soil and Water Matrices[J],2022,9(8).
APA	Franklin, Alison M.,Andrews, Danielle M.,Williams, Clinton F.,&Watson, John E..(2022).Simultaneous Extraction of Four Antibiotic Compounds from Soil and Water Matrices.SEPARATIONS,9(8).
MLA	Franklin, Alison M.,et al."Simultaneous Extraction of Four Antibiotic Compounds from Soil and Water Matrices".SEPARATIONS 9.8(2022).