干旱区生态环境知识资源中心(Arid): Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study

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DOI	10.1186/s12931-022-02154-y
	Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study
	Cano-Jimenez, Esteban; Romero Ortiz, Ana Dolores; Villar, Ana; Jesus Rodriguez-Nieto, Maria; Ramon, Alba; Armengol, Silvia
通讯作者	Cano-Jiménez, E
来源期刊	RESPIRATORY RESEARCH
EISSN	1465-993X
出版年	2022
卷号	23 期号:1
英文摘要	Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease associated with decline in lung function and poor prognosis entailing significant impairment in quality of life and high socioeconomic burden. The aim of this study was to characterize clinical management and resources utilization of patients with IPF in Spain, according to predicted forced vital capacity (FVC) % at baseline. Methods Prospective, non-interventional, multicentric real-world data study in patients with IPF in Spain with 12-months follow-up. Clinical management and resources utilization during study period were recorded and compared between groups. FVC decline and acute exacerbations occurrence and associated healthcare resource use were also analysed. FVC decline after 12 months was estimated as relative change. Results 204 consecutive patients with IPF were included and divided according to baseline FVC % predicted value. At baseline, patients with FVC < 50% received significantly more pharmacological and non-pharmacological treatments, and more help from caregiver. During the 12-months follow-up, patients with FVC < 50% required more specialized care visits, emergency visits, hospitalizations, pulmonary functions tests, non-health resource use (special transportation), and pharmacological treatments (p < 0.05 for all comparisons). Moreover, patients with FVC < 50% at baseline experienced more AE-IPF (p < 0.05), requiring more health-related resources use (primary care visits, p < 0.05). FVC decline was observed in all groups over the 12 months. FVC decreased on average by 2.50% (95% CI: - 5.98 to 0.98) along the year. More patients experienced an FVC decline > 10% in the more preserved lung function groups than in the FVC < 50% group, because of their already deteriorated condition. Conclusions We observed a significantly higher annual IPF-related resource use in patients with more impaired lung function at baseline. Since FVC decreases irrespective of FVC% predicted at baseline, slowing IPF progression to maintain patients at early disease stages is relevant to improve IPF management and to optimize resource use. Trial registration: EU PAS register number EUPAS19387 [June 01, 2017].
英文关键词	Idiopathic pulmonary fibrosis (IPF) Clinical management IPF acute exacerbations IPF management IPF progression Early treatment
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000852465600002
WOS关键词	NINTEDANIB ; PIRFENIDONE ; GUIDELINES ; DIAGNOSIS ; MORTALITY ; IMPACT
WOS类目	Respiratory System
WOS研究方向	Respiratory System
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/394273
推荐引用方式 GB/T 7714	Cano-Jimenez, Esteban,Romero Ortiz, Ana Dolores,Villar, Ana,et al. Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study[J],2022,23(1).
APA	Cano-Jimenez, Esteban,Romero Ortiz, Ana Dolores,Villar, Ana,Jesus Rodriguez-Nieto, Maria,Ramon, Alba,&Armengol, Silvia.(2022).Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study.RESPIRATORY RESEARCH,23(1).
MLA	Cano-Jimenez, Esteban,et al."Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study".RESPIRATORY RESEARCH 23.1(2022).