干旱区生态环境知识资源中心(Arid): Calculating the individual probability of successful ocriplasmin treatment in eyes with vitreomacular traction-Validation and refinement of a multivariable prediction model

Arid

DOI	10.1371/journal.pone.0270120
	Calculating the individual probability of successful ocriplasmin treatment in eyes with vitreomacular traction-Validation and refinement of a multivariable prediction model
	Paul, Christoph; Mueller, Hans-Helge; Raber, Thomas; Bertelmann, Thomas
通讯作者	Paul, C
来源期刊	PLOS ONE
ISSN	1932-6203
出版年	2022
卷号	17 期号:7
英文摘要	Purpose To evaluate a multivariable model predicting the individual probability of successful intravitreal ocriplasmin (IVO) treatment in eyes with vitreomacular traction (VMT). Methods Data from three prospective, multicenter IVO studies (OASIS, ORBIT, and INJECT) were pooled. Patients were included if they were treated for a symptomatic VMT without a full-thickness macular hole. A prediction model for VMT resolution using the factors 'age' and 'horizontal VMT diameter' was validated by receiver operating characteristic analysis and according to grouped prediction after calibration. Multivariable regression analysis was performed to check robustness and explore further improvements. Results Data from 591 eyes was included. In the univariate analysis all key factors (age, gender, VMT diameter, lens status, ERM) significantly correlated to treatment success. The prediction model was robust and clinically applicable to estimate the success rate of IVO treatment (AUC of ROC: 0.70). A refinement of the model was achieved through a calibration process. Conclusion The developed multivariable model using 'horizontal VMT diameter' and 'age' is a valid tool for prediction of VMT resolution upon IVO treatment.
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000892932200015
WOS关键词	MACULAR HOLE ; SPONTANEOUS RESOLUTION ; SAFETY PROFILE ; ADHESION ; RELEASE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/394033
推荐引用方式 GB/T 7714	Paul, Christoph,Mueller, Hans-Helge,Raber, Thomas,et al. Calculating the individual probability of successful ocriplasmin treatment in eyes with vitreomacular traction-Validation and refinement of a multivariable prediction model[J],2022,17(7).
APA	Paul, Christoph,Mueller, Hans-Helge,Raber, Thomas,&Bertelmann, Thomas.(2022).Calculating the individual probability of successful ocriplasmin treatment in eyes with vitreomacular traction-Validation and refinement of a multivariable prediction model.PLOS ONE,17(7).
MLA	Paul, Christoph,et al."Calculating the individual probability of successful ocriplasmin treatment in eyes with vitreomacular traction-Validation and refinement of a multivariable prediction model".PLOS ONE 17.7(2022).