干旱区生态环境知识资源中心(Arid): The Anti-Candida Activity of Tephrosia apollinea Is More Superiorly Attributed to a Novel Steroidal Compound with Selective Targeting

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DOI	10.3390/plants11162120
	The Anti-Candida Activity of Tephrosia apollinea Is More Superiorly Attributed to a Novel Steroidal Compound with Selective Targeting
	Ashmawy, Naglaa S.; El-labbad, Eman M.; Hamoda, Alshaimaa M.; El-Keblawy, Ali A.; El-Shorbagi, Abdel-Nasser A.; Mosa, Kareem A.; Soliman, Sameh S. M.
通讯作者	Soliman, SSM
来源期刊	PLANTS-BASEL
ISSN	2223-7747
出版年	2022
卷号	11 期号:16
英文摘要	Tephrosia is widely distributed throughout tropical, subtropical, and arid regions. This genus is known for several biological activities, including its anti Candida activity, which is mainly attributed to prenylated flavonoids. The biological activities of most Tephrosia species have been studied, except T. apollinea. This study was conducted to investigate the underlying anti Candida activity of T. apollinea, wildly grown in the United Arab Emirates (UAE). The T. apollinea plant was collected, dried, and the leaves were separated. The leaves were ground and extracted. The dried extract was subjected to successive chromatography to identify unique phytochemicals with a special pharmacological activity. The activity of the compound was validated by homology modeling and molecular docking studies. A novel steroidal compound (ergosta-6, 8(14), 22, 24(28)-tetraen-3-one) was isolated and named TNS. In silico target identification of TNS revealed a high structural similarity with the Candida 14-alpha-demethylase enzyme substrate. The compound exhibited a significant anti-Candida activity, specifically against the multi-drug-resistant Candida auris at MIC50, 16 times less than the previously reported prenylated flavonoids and 5 times less than the methanol extract of the plant. These findings were supported by homology modeling and molecular docking studies. TNS may represent a new class of Candida 14-alpha-demethylase inhibitors.
英文关键词	Tephrosia apollinea anti-Candida hot arid desert novel steroid natural optimization
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000845686900001
WOS关键词	ERGOSTANE-TYPE STEROIDS ; PRENYLATED FLAVONOIDS ; PURPUREA
WOS类目	Plant Sciences
WOS研究方向	Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/393998
推荐引用方式 GB/T 7714	Ashmawy, Naglaa S.,El-labbad, Eman M.,Hamoda, Alshaimaa M.,et al. The Anti-Candida Activity of Tephrosia apollinea Is More Superiorly Attributed to a Novel Steroidal Compound with Selective Targeting[J],2022,11(16).
APA	Ashmawy, Naglaa S..,El-labbad, Eman M..,Hamoda, Alshaimaa M..,El-Keblawy, Ali A..,El-Shorbagi, Abdel-Nasser A..,...&Soliman, Sameh S. M..(2022).The Anti-Candida Activity of Tephrosia apollinea Is More Superiorly Attributed to a Novel Steroidal Compound with Selective Targeting.PLANTS-BASEL,11(16).
MLA	Ashmawy, Naglaa S.,et al."The Anti-Candida Activity of Tephrosia apollinea Is More Superiorly Attributed to a Novel Steroidal Compound with Selective Targeting".PLANTS-BASEL 11.16(2022).