干旱区生态环境知识资源中心(Arid): Serrulatane diterpenoids with unusual side chain modifications from root bark of Eremophila longifolia

Arid

DOI	10.1016/j.phytochem.2022.113408
	Serrulatane diterpenoids with unusual side chain modifications from root bark of Eremophila longifolia
	Rasmussen, Line Fentz; Anton, Jennifer; Kjaerulff, Louise; Zhao, Yong; Semple, Susan J.; Chi, Ndi; Buirchell, Bevan; Moller, Birger Lindberg; Staerk, Dan
通讯作者	Staerk, D
来源期刊	PHYTOCHEMISTRY
ISSN	0031-9422
EISSN	1873-3700
出版年	2022
卷号	203
英文摘要	The plant genus Eremophila is endemic to Australia and widespread in arid regions. Root bark extract of Ere-mophila longifolia (R.Br.) F.Muell. (Scrophulariaceae) was investigated by LC-PDA-HRMS, and dereplication suggested the presence of a series of diterpenoids. Using a combination of preparative-and analytical-scale HPLC separation as well as extensive 1D and 2D NMR analysis, the structures of 12 hitherto unreported serrulatane diterpenoids, eremolongine A-L, were established. These structures included serrulatanes with unusual side chain modifications to form hitherto unseen skeletons with, e.g., cyclopentane, oxepane, and bicyclic hexahydro-1H- cyclopenta[c]furan moieties. Serrulatane diterpenoids in Eremophila have recently been shown to originate from a common biosynthetic precursor with conserved stereochemical configuration, and this was used for tentative assignment of the relative and absolute configuration of the isolated compounds. Triple high-resolution alpha-glucosidase/alpha-amylase/PTP1B inhibition profiling demonstrated that several of the eremolongines had weak inhibitory activity towards targets important for management of type 2 diabetes.
英文关键词	Scrophulariaceae Serrulatane diterpenoids High-resolution inhibition profiling ?-Glucosidase ?-Amylase Protein-tyrosine phosphatase 1B Eremophila longifolia (R Br ) F Muell
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000860734200002
WOS关键词	MAGNETIC-RESONANCE-SPECTROSCOPY ; PROOF-OF-CONCEPT ; ANTIDIABETIC CONSTITUENTS ; CRUDE EXTRACT ; IDENTIFICATION ; SCROPHULARIACEAE ; INHIBITORS ; PTP1B
WOS类目	Biochemistry & Molecular Biology ; Plant Sciences
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/393948
推荐引用方式 GB/T 7714	Rasmussen, Line Fentz,Anton, Jennifer,Kjaerulff, Louise,et al. Serrulatane diterpenoids with unusual side chain modifications from root bark of Eremophila longifolia[J],2022,203.
APA	Rasmussen, Line Fentz.,Anton, Jennifer.,Kjaerulff, Louise.,Zhao, Yong.,Semple, Susan J..,...&Staerk, Dan.(2022).Serrulatane diterpenoids with unusual side chain modifications from root bark of Eremophila longifolia.PHYTOCHEMISTRY,203.
MLA	Rasmussen, Line Fentz,et al."Serrulatane diterpenoids with unusual side chain modifications from root bark of Eremophila longifolia".PHYTOCHEMISTRY 203(2022).