干旱区生态环境知识资源中心(Arid): The Importance of Endoplasmic Reticulum Stress as a Novel Antidepressant Drug Target and Its Potential Impact on CNS Disorders

Arid

DOI	10.3390/pharmaceutics14040846
	The Importance of Endoplasmic Reticulum Stress as a Novel Antidepressant Drug Target and Its Potential Impact on CNS Disorders
	Jozwiak-Bebenista, Marta; Sokolowska, Paulina; Siatkowska, Malgorzata; Panek, Cecilia Analia; Komorowski, Piotr; Kowalczyk, Edward; Wiktorowska-Owczarek, Anna
通讯作者	Józwiak-Bebenista, M
来源期刊	PHARMACEUTICS
EISSN	1999-4923
出版年	2022
卷号	14 期号:4
英文摘要	Many central nervous system (CNS) diseases, including major depressive disorder (MDD), are underpinned by the unfolded protein response (UPR) activated under endoplasmic reticulum (ER) stress. New, more efficient, therapeutic options for MDD are needed to avoid adverse effects and drug resistance. Therefore, the aim of the work was to determine whether UPR signalling pathway activation in astrocytes may serve as a novel target for antidepressant drugs. Among the tested antidepressants (escitalopram, amitriptyline, S-ketamine and R-ketamine), only S-ketamine, and to a lesser extent R-ketamine, induced the expression of most ER stress-responsive genes in astrocytes. Furthermore, cell viability and apoptosis measuring assays showed that (R-)S-ketamine did not affect cell survival under ER stress. Under normal conditions, S-ketamine played the key role in increasing the release of brain-derived neurotrophic factor (BDNF), indicating that the drug has a complex mechanism of action in astrocytes, which may contribute to its therapeutic effects. Our findings are the first to shed light on the relationship between old astrocyte specifically induced substance (OASIS) stabilized by ER stress and (R-)S-ketamine; however, the possible involvement of OASIS in the mechanism of therapeutic ketamine action requires further study.
英文关键词	antidepressant drugs CHOP depression ER stress ketamine OASIS UPR pathway
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000786060600001
WOS关键词	ER STRESS ; TRANSMEMBRANE PROTEIN ; OXIDATIVE STRESS ; NEUROTROPHIC FACTOR ; KETAMINE ; BRAIN ; EXPRESSION ; DEPRESSION ; APOPTOSIS ; PATHOLOGY
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/393934
推荐引用方式 GB/T 7714	Jozwiak-Bebenista, Marta,Sokolowska, Paulina,Siatkowska, Malgorzata,et al. The Importance of Endoplasmic Reticulum Stress as a Novel Antidepressant Drug Target and Its Potential Impact on CNS Disorders[J],2022,14(4).
APA	Jozwiak-Bebenista, Marta.,Sokolowska, Paulina.,Siatkowska, Malgorzata.,Panek, Cecilia Analia.,Komorowski, Piotr.,...&Wiktorowska-Owczarek, Anna.(2022).The Importance of Endoplasmic Reticulum Stress as a Novel Antidepressant Drug Target and Its Potential Impact on CNS Disorders.PHARMACEUTICS,14(4).
MLA	Jozwiak-Bebenista, Marta,et al."The Importance of Endoplasmic Reticulum Stress as a Novel Antidepressant Drug Target and Its Potential Impact on CNS Disorders".PHARMACEUTICS 14.4(2022).