干旱区生态环境知识资源中心(Arid): Accelerated evolution of Vkorc1 in desert rodent species reveals genetic preadaptation to anticoagulant rodenticides

Arid

DOI	10.1002/ps.6905
	Accelerated evolution of Vkorc1 in desert rodent species reveals genetic preadaptation to anticoagulant rodenticides
	Chen, Yan; Wang, Dawei; Li, Ning; Wang, Deng; Liu, Xiao-Hui; Song, Ying
通讯作者	Liu, XH ; Song, Y
来源期刊	PEST MANAGEMENT SCIENCE
ISSN	1526-498X
EISSN	1526-4998
出版年	2022
卷号	78 期号:6 页码:2704-2713
英文摘要	BACKGROUND: Some rodent species living in arid areas show elevated physiological tolerance to anti-vitamin K rodenticides (AVKs), which seems to be due to some unknown selective pressures that rodents may experience in desert habitats. Genes involved in the Upsilon-carboxylation of blood coagulation, including vitamin K epoxide reductase complex, subunit 1 (Vkorc1), Upsilon-glutamyl-carboxylase (Ggcx) and NAD(P)H quinone one dehydrogenase (Nqo1) are associated with anticoagulant resistance, or some levels of elevated tolerance, in rodents. To detect whether the DNA sequences of the three genes are also under natural selection in the desert rodent species, we analyzed the Vkorc1, Ggcx and Nqo1 genes of the desert rodents and compared them with other rodent species. RESULTS: We found an accelerated evolutionary rate in Vkorc1 of desert rodents, especially in Mus spretus, Nannospalax galili and Psammomys obesus. By contrast, signals of positive selection were absent for Ggcx and Nqo1 in all species. Mapping the amino acid variations on the VKORC1 protein three-dimensional model suggested most interspecific amino acid variations occur on the outer surface of the VKORC1 pocket, whereas most intraspecific amino acid changes and known AVK resistance mutations occurred on the inner surface and endoplasmic reticulum luminal loop regions. Some desert-species-specific amino acid variations were found on the positions where known resistance mutations occurred, indicating these variations might be related to the elevated physical tolerance to AVKs in desert rodents. CONCLUSION: The evolution of Vkorc1 has been accelerated in some desert rodent species, indicating genetic preadaptation to anticoagulant rodenticides. Positive selection and relaxed selection have been detected in Psammomys obesus and Nannospalax galili, indicating the two rodent species might also show tolerance to AVKs, which needs further verification. (C) 2022 Society of Chemical Industry.
英文关键词	rodent anticoagulant rodenticides elevated physiological tolerance Vkorc1 Ggcx adaptation
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000786579700001
WOS关键词	DETECTING POSITIVE SELECTION ; MUS-MUSCULUS-DOMESTICUS ; VITAMIN-K REQUIREMENT ; RAT RATTUS-NORVEGICUS ; AMINO-ACID SITES ; WARFARIN RESISTANCE ; INFERENCE ; WILD ; SUBSTITUTIONS ; POLYMORPHISM
WOS类目	Agronomy ; Entomology
WOS研究方向	Agriculture ; Entomology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/393931
推荐引用方式 GB/T 7714	Chen, Yan,Wang, Dawei,Li, Ning,et al. Accelerated evolution of Vkorc1 in desert rodent species reveals genetic preadaptation to anticoagulant rodenticides[J],2022,78(6):2704-2713.
APA	Chen, Yan,Wang, Dawei,Li, Ning,Wang, Deng,Liu, Xiao-Hui,&Song, Ying.(2022).Accelerated evolution of Vkorc1 in desert rodent species reveals genetic preadaptation to anticoagulant rodenticides.PEST MANAGEMENT SCIENCE,78(6),2704-2713.
MLA	Chen, Yan,et al."Accelerated evolution of Vkorc1 in desert rodent species reveals genetic preadaptation to anticoagulant rodenticides".PEST MANAGEMENT SCIENCE 78.6(2022):2704-2713.