干旱区生态环境知识资源中心(Arid): Antimicrobial Triterpenoids and Ingol Diterpenes from Propolis of Semi-Arid Region of Morocco

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DOI	10.3390/molecules27072206
	Antimicrobial Triterpenoids and Ingol Diterpenes from Propolis of Semi-Arid Region of Morocco
	Chimshirova, Ralitsa; Popova, Milena; Chakir, Amina; Valcheva, Violeta; Dimitrov, Simeon; Trusheva, Boryana; Romane, Abderrahmane; Bankova, Vassya
通讯作者	Popova, M
来源期刊	MOLECULES
EISSN	1420-3049
出版年	2022
卷号	27 期号:7
英文摘要	The chemical composition and antimicrobial activity of propolis from a semi-arid region of Morocco were investigated. Fifteen compounds, including triterpenoids (1, 2, 7-12), macrocyclic diterpenes of ingol type (3-6) and aromatic derivatives (13-15), were isolated by various chromatographic methods. Their structures were elucidated by a combination of spectroscopic and chiroptical methods. Compounds 1 and 3 are new natural compounds, and 2, 4-6, and 9-11 are newly isolated from propolis. Moreover, the full nuclear magnetic resonance (NMR) assignments of three of the known compounds (2, 4 and 5) were reported for the first time. Most of the compounds tested, especially the diterpenes 3, 4, and 6, exhibited very good activity against different strains of bacteria and fungi. Compound 3 showed the strongest activity with minimum inhibitory concentrations (MICs) in the range of 4-64 mu g/mL. The combination of isolated triterpenoids and ingol diterpenes was found to be characteristic for Euphorbia spp., and Euphorbia officinarum subsp. echinus could be suggested as a probable and new plant source of propolis.
英文关键词	propolis triterpenoids ingol diterpenes antimicrobial activity Euphorbia spp Morocco
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000780578800001
WOS关键词	PLANT-ORIGIN ; CHEMICAL-CONSTITUENTS ; TIRUCALLANE TRITERPENES ; DERIVATIVES ; EUPHORBIUM ; CHEMISTRY ; IRRITANT ; BEHAVIOR ; STEROIDS ; DIVERSE
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/393815
推荐引用方式 GB/T 7714	Chimshirova, Ralitsa,Popova, Milena,Chakir, Amina,et al. Antimicrobial Triterpenoids and Ingol Diterpenes from Propolis of Semi-Arid Region of Morocco[J],2022,27(7).
APA	Chimshirova, Ralitsa.,Popova, Milena.,Chakir, Amina.,Valcheva, Violeta.,Dimitrov, Simeon.,...&Bankova, Vassya.(2022).Antimicrobial Triterpenoids and Ingol Diterpenes from Propolis of Semi-Arid Region of Morocco.MOLECULES,27(7).
MLA	Chimshirova, Ralitsa,et al."Antimicrobial Triterpenoids and Ingol Diterpenes from Propolis of Semi-Arid Region of Morocco".MOLECULES 27.7(2022).