干旱区生态环境知识资源中心(Arid): Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms

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DOI	10.1016/j.leukres.2022.106883
	Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms
	De Marchi, Federico; Okuda, Maho; Morishita, Soji; Imai, Misa; Baba, Terumi; Horino, Mei; Mori, Yosuke; Furuya, Chiho; Ogata, Satoko; Yang, Yinjie; Ando, Jun; Ando, Miki; Araki, Marito; Komatsu, Norio
通讯作者	Komatsu, N
来源期刊	LEUKEMIA RESEARCH
ISSN	0145-2126
EISSN	1873-5835
出版年	2022
卷号	119
英文摘要	Cyclic AMP-response element-binding protein 3-like 1 (CREB3L1) is a gene involved in the unfolded protein response (UPR). Recently, we demonstrated that CREB3L1 is specifically overexpressed in the platelets of patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). In this study, we aimed to show the clinical and biological relevance of CREB3L1 in these hematological diseases. Overexpression of CREB3L1 was specific to platelets in MPNs and associated with a higher risk of thrombosis and fibrotic transformation in essential thrombocythemia (ET) and polycythemia vera (PV) cases, respectively. Furthermore, we found that UPR genes were downregulated in platelets of patients with ET and PV, which were more pronounced in patients harboring the JAK2 V617F mutation. However, CREB3L1 overexpression does not alter UPR gene expression or cell proliferation in UT-7/TPO/CALRm cells exogenously expressing mutated calreticulin and HEL cells harboring endogenous JAK2 V617F. Furthermore, CREB3L1 overexpression did not modulate sensitivity to endoplasmic reticulum stress in these cell lines. Taken together, our data show 1) a potential role of CREB3L1 expression in platelets as a new marker of high-risk MPNs and 2) an association between CREB3L1 over expression and UPR gene downregulation in these patients' platelets, with CREB3L1 not altering UPR in our in vitro models and possibly further in vivo mechanisms being involved.
英文关键词	CREB3L1 JAK2 CALR Philadelphia chromosome-negative myelopro-liferative neoplasms (MPNs) Platelet RNA Unfolded protein response (UPR)
类型	Article
语种	英语
开放获取类型	Green Published
收录类别	SCI-E
WOS记录号	WOS:000815781900003
WOS关键词	ENDOPLASMIC-RETICULUM STRESS ; UNFOLDED PROTEIN RESPONSE ; MEGAKARYOCYTIC CELL-LINE ; TRANSCRIPTION FACTOR ; CANCER ; OASIS ; ESTABLISHMENT ; EXPRESSION ; HEALTH ; FAMILY
WOS类目	Oncology ; Hematology
WOS研究方向	Oncology ; Hematology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/393749
推荐引用方式 GB/T 7714	De Marchi, Federico,Okuda, Maho,Morishita, Soji,et al. Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms[J],2022,119.
APA	De Marchi, Federico.,Okuda, Maho.,Morishita, Soji.,Imai, Misa.,Baba, Terumi.,...&Komatsu, Norio.(2022).Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms.LEUKEMIA RESEARCH,119.
MLA	De Marchi, Federico,et al."Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms".LEUKEMIA RESEARCH 119(2022).