干旱区生态环境知识资源中心(Arid): Ultrafast and high-throughput quantitative analysis of carbamazepine in human plasma by direct analysis in real time tandem mass spectrometry coupled with solid phase extraction to eliminate matrix effects

Arid

DOI	10.1016/j.jpba.2022.114751
	Ultrafast and high-throughput quantitative analysis of carbamazepine in human plasma by direct analysis in real time tandem mass spectrometry coupled with solid phase extraction to eliminate matrix effects
	Shi, Meiyun; Zheng, Xinyue; Lu, Di; Duan, Xujian; Wang, Yongqi; Liu, Yajun; Xue, Hongyu; Yin, Lei
通讯作者	Yin, L
来源期刊	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN	0731-7085
EISSN	1873-264X
出版年	2022
卷号	214
英文摘要	Therapeutic drug monitoring of carbamazepine is necessary for its clinical application with the purpose to reach therapeutic concentration and reduce the risk of concentration-dependent toxicity. An ultrafast analytical assay for quantification of carbamazepine in human plasma was developed and validated based on direct analysis in real time tandem mass spectrometry (DART-MS/MS). After reversed phase solid phase extraction with Waters Oasis HLB, carbamazepine and internal standard carbamazepine-D2N15 were monitored by positive ion mode followed by multiple reaction monitoring (MRM) of the transitions at m/z 237.1 -> 194.0 and 240.1 -> 196.2, respectively. The DART-MS/MS method is ultrafast and high-throughput and the analytical time for each sample is only 0.4 min. The assay was linear in the concentration range 0.50-30 mu g/mL and intra- and inter-day accuracies were within +/- 15% and trueness were < 13.9% at all concentrations. The method was successfully applied to therapeutic drug monitoring of carbamazepine in human plasma.
英文关键词	Therapeutic drug monitoring DART-MS MS Carbamazepine
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000793640900010
WOS关键词	BIOANALYTICAL METHOD VALIDATION ; LC-MS/MS METHOD ; HPLC-UV METHOD ; QUANTIFICATION ; EPILEPSY ; LAMOTRIGINE ; PRIMIDONE ; PHENYTOIN ; ADDITIVES ; CHILDREN
WOS类目	Chemistry, Analytical ; Pharmacology & Pharmacy
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/393566
推荐引用方式 GB/T 7714	Shi, Meiyun,Zheng, Xinyue,Lu, Di,et al. Ultrafast and high-throughput quantitative analysis of carbamazepine in human plasma by direct analysis in real time tandem mass spectrometry coupled with solid phase extraction to eliminate matrix effects[J],2022,214.
APA	Shi, Meiyun.,Zheng, Xinyue.,Lu, Di.,Duan, Xujian.,Wang, Yongqi.,...&Yin, Lei.(2022).Ultrafast and high-throughput quantitative analysis of carbamazepine in human plasma by direct analysis in real time tandem mass spectrometry coupled with solid phase extraction to eliminate matrix effects.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,214.
MLA	Shi, Meiyun,et al."Ultrafast and high-throughput quantitative analysis of carbamazepine in human plasma by direct analysis in real time tandem mass spectrometry coupled with solid phase extraction to eliminate matrix effects".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 214(2022).