干旱区生态环境知识资源中心(Arid): Genome Organization and Copy-Number Variation Reveal Clues to Virulence Evolution in Coccidioides posadasii

Arid

DOI	10.3390/jof8121235
	Genome Organization and Copy-Number Variation Reveal Clues to Virulence Evolution in Coccidioides posadasii
	Dubin, Claire A. A.; Voorhies, Mark; Sil, Anita; Teixeira, Marcus M. M.; Barker, Bridget M. M.; Brem, Rachel B. B.
通讯作者	Brem, RB
来源期刊	JOURNAL OF FUNGI
EISSN	2309-608X
出版年	2022
卷号	8 期号:12
英文摘要	The human fungal pathogen Coccidioides spp. causes valley fever, a treatment-refractory and sometimes deadly disease prevalent in arid regions of the western hemisphere. Fungal virulence in the mammalian host hinges on a switch between growth as hyphae and as large spherules containing infectious spores. How these virulence programs are encoded in the genome remains poorly understood. Drawing on Coccidioides genomic resources, we first discovered a new facet of genome organization in this system: spherule-gene islands, clusters of genes physically linked in the genome that exhibited specific mRNA induction in the spherule phase. Next, we surveyed copy-number variation genome-wide among strains of C. posadasii. Emerging from this catalog were spherule-gene islands with striking presence-absence differentiation between C. posadasii populations, a pattern expected from virulence factors subjected to different selective pressures across habitats. Finally, analyzing single-nucleotide differences across C. posadasii strains, we identified signatures of natural selection in spherule-expressed genes. Together, our data establish spherule-gene islands as candidate determinants of virulence and targets of selection in Coccidioides.
英文关键词	Coccidioides virulence fungal pathogens copy number variation genome organization
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000900694800001
WOS关键词	IMMITIS ; LIFE ; PATTERNS
WOS类目	Microbiology ; Mycology
WOS研究方向	Microbiology ; Mycology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/393444
推荐引用方式 GB/T 7714	Dubin, Claire A. A.,Voorhies, Mark,Sil, Anita,et al. Genome Organization and Copy-Number Variation Reveal Clues to Virulence Evolution in Coccidioides posadasii[J],2022,8(12).
APA	Dubin, Claire A. A.,Voorhies, Mark,Sil, Anita,Teixeira, Marcus M. M.,Barker, Bridget M. M.,&Brem, Rachel B. B..(2022).Genome Organization and Copy-Number Variation Reveal Clues to Virulence Evolution in Coccidioides posadasii.JOURNAL OF FUNGI,8(12).
MLA	Dubin, Claire A. A.,et al."Genome Organization and Copy-Number Variation Reveal Clues to Virulence Evolution in Coccidioides posadasii".JOURNAL OF FUNGI 8.12(2022).