干旱区生态环境知识资源中心(Arid): Brain Age Difference at Baseline Predicts Clinical Dementia Rating Change in Approximately Two Years

Arid

DOI	10.3233/JAD-215380
	Brain Age Difference at Baseline Predicts Clinical Dementia Rating Change in Approximately Two Years
	Tseng, Wen-Yih Isaac; Hsu, Yung-Chin; Kao, Te-Wei
通讯作者	Tseng, WYI
来源期刊	JOURNAL OF ALZHEIMERS DISEASE
ISSN	1387-2877
EISSN	1875-8908
出版年	2022
卷号	86 期号:2 页码:613-627
英文摘要	Background: The Clinical Dementia Rating (CDR) has been widely used to assess dementia severity, but it is limited in predicting dementia progression, thus unable to advise preventive measures to those who are at high risk. Objective: Predicted age difference (PAD) was proposed to predict CDR change. Methods: All diffusion magnetic resonance imaging and CDR scores were obtained from the OASIS-3 databank. A brain age model was trained by a machine learning algorithm using the imaging data of 258 cognitively healthy adults. Two diffusion indices, i.e., mean diffusivity and fractional anisotropy, over the whole brain white matter were extracted to serve as the features for model training. The validated brain age model was applied to a longitudinal cohort of 217 participants who had CDR = 0 (CDRO), 0.5 (CDR0.5), and 1 (CDR1) at baseline. Participants were grouped according to different baseline CDR and their subsequent CDR in approximately 2 years of follow-up. PAD was compared between different groups with multiple comparison correction. Results: PADs were significantly different among participants with different baseline CDRs. PAD in participants with relatively stable CDR0.5 was significantly smaller than PAD in participants who had CDR0.5 at baseline but converted to CDR1 in the follow-up. Similarly, participants with relatively stable CDRO had significantly smaller PAD than those who were CDRO at baseline but converted to CDR0.5 in the follow-up. Conclusion: Our results imply that PAD might be a potential imaging biomarker for predicting CDR outcomes in patients with CDRO or CDR0.5.
英文关键词	Brain age dementia diffusion MRI predicted age difference
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000773411100010
WOS关键词	MILD COGNITIVE IMPAIRMENT ; ALZHEIMER-DISEASE ; RISK-FACTORS ; LIFE-STYLE ; SCALE ; PROGRESSION ; SCORE
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/393276
推荐引用方式 GB/T 7714	Tseng, Wen-Yih Isaac,Hsu, Yung-Chin,Kao, Te-Wei. Brain Age Difference at Baseline Predicts Clinical Dementia Rating Change in Approximately Two Years[J],2022,86(2):613-627.
APA	Tseng, Wen-Yih Isaac,Hsu, Yung-Chin,&Kao, Te-Wei.(2022).Brain Age Difference at Baseline Predicts Clinical Dementia Rating Change in Approximately Two Years.JOURNAL OF ALZHEIMERS DISEASE,86(2),613-627.
MLA	Tseng, Wen-Yih Isaac,et al."Brain Age Difference at Baseline Predicts Clinical Dementia Rating Change in Approximately Two Years".JOURNAL OF ALZHEIMERS DISEASE 86.2(2022):613-627.