干旱区生态环境知识资源中心(Arid): Hippocampus-Based Dynamic Functional Connectivity Mapping in the Early Stages of Alzheimer's Disease

Arid

DOI	10.3233/JAD-215239
	Hippocampus-Based Dynamic Functional Connectivity Mapping in the Early Stages of Alzheimer's Disease
	Wang, Jianlin; Wang, Pan; Jiang, Yuan; Wang, Zedong; Zhang, Hong; Li, Hongyi; Biswal, Bharat B.
通讯作者	Wang, P ; Biswal, BB
来源期刊	JOURNAL OF ALZHEIMERS DISEASE
ISSN	1387-2877
EISSN	1875-8908
出版年	2022
卷号	85 期号:4 页码:1795-1806
英文摘要	Background: The hippocampus with varying degrees of atrophy was a crucial neuroimaging feature resulting in the declining memory and cognitive function in Alzheimer's disease (AD). However, the abnormal dynamic functional connectivity (DFC) in both white matter (WM) and gray matter (GM) from the left and right hippocampus remains unclear. Objective: To explore the abnormal DFC within WM and GM from the left and right hippocampus across the different stages of AD. Methods: Current study employed the OASIS-3 dataset including 43 mild cognitive impairment (MCI), 71 pre-mild cognitive impairment (pre-MCI), and matched 87 normal cognitive (NC). Adopting the FMRIB's Integrated Registration and Segmentation Tool, we obtained the left and right hippocampus mask. Based on above hippocampus mask as seed point, we calculated the DFC between left/right hippocampus and all voxel time series within whole brain. One-way ANOVA analysis was performed to estimate the abnormal DFC among MCI, pre-MCI, and NC groups. Results: We found that MCI and pre-MCI groups showed the common abnormalities of DFC in the Temporal_Mid_L, Cingulum_Mid_L, and Thalamus_L. Specific abnormalities were found in the Cerebelum_9_L and Precuneus of MCI group and Vermis_8 and Caudate_L of pre-MCI group. In addition, we found that DFC within WM regions also showed the common low DFC for the Cerebellum anterior lobe-WM, Corpus callosum, and Frontal lobe-WM in MCI and pre-MCI group. Conclusion: Our findings provided a novel information for discover the pathophysiological mechanisms of AD and indicate WM lesions were also an important cause of cognitive decline in AD.
英文关键词	Alzheimer's disease dynamic functional connectivity hippocampus mild cognitive impairment white matter BOLD signal
类型	Article
语种	英语
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000759157200032
WOS关键词	MILD COGNITIVE IMPAIRMENT ; TENSOR IMAGING MEASURES ; WHITE-MATTER ; BRAIN NETWORKS ; SEGMENTATION ; PROGRESSION ; CEREBELLUM ; POSTERIOR ; MCI
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/393275
推荐引用方式 GB/T 7714	Wang, Jianlin,Wang, Pan,Jiang, Yuan,et al. Hippocampus-Based Dynamic Functional Connectivity Mapping in the Early Stages of Alzheimer's Disease[J],2022,85(4):1795-1806.
APA	Wang, Jianlin.,Wang, Pan.,Jiang, Yuan.,Wang, Zedong.,Zhang, Hong.,...&Biswal, Bharat B..(2022).Hippocampus-Based Dynamic Functional Connectivity Mapping in the Early Stages of Alzheimer's Disease.JOURNAL OF ALZHEIMERS DISEASE,85(4),1795-1806.
MLA	Wang, Jianlin,et al."Hippocampus-Based Dynamic Functional Connectivity Mapping in the Early Stages of Alzheimer's Disease".JOURNAL OF ALZHEIMERS DISEASE 85.4(2022):1795-1806.