干旱区生态环境知识资源中心(Arid): Herbal Medicine Intervention for the Treatment of COVID-19: A Living Systematic Review and Cumulative Meta-Analysis

Arid

DOI	10.3389/fphar.2022.906764
	Herbal Medicine Intervention for the Treatment of COVID-19: A Living Systematic Review and Cumulative Meta-Analysis
	Ang, Lin; Song, Eunhye; Hu, Xiao-Yang; Lee, Hye Won; Chen, Yaolong; Lee, Myeong Soo
通讯作者	Lee, MS
来源期刊	FRONTIERS IN PHARMACOLOGY
EISSN	1663-9812
出版年	2022
卷号	13
英文摘要	Background: Integrative herbal medicine has been reported to have beneficial effects in the treatment of coronavirus disease 2019 (COVID-19). Aim: To compile up-to-date evidence of the benefits and risks of herbal medicine for the treatment of COVID-19 symptoms. Methods: Eleven databases, including PubMed, Cochrane Register of Controlled Trials (CENTRAL), Embase, Allied and Complementary Medicine Database (AMED), Chinese National Knowledge Infrastructure Database (CNKI), Wanfang Database, and Chinese Science and Technique Journals Database (VIP), Research Information Service System (RISS), Korean Medical database (KMBase), Korean Association of Medical Journal database (KoreaMed), and OASIS database, were searched from 15 June, 2020, until 28 March 2022. Randomized controlled trials (RCTs), published in any language, reporting the efficacy and safety outcomes of herbal medicine in patients of all ages with a PCR-confirmed diagnosis of COVID-19 were included in this analysis. Data extraction and quality assessments were performed independently. Results: Random-effects meta-analyses showed evidence of favorable effects of treatment with herbal medicine when added to standard treatment, versus standard treatment alone, on the total effective rate (p = 0.0001), time to remission from fever (p < 0.00001), rate of remission from coughing (p < 0.0001), fatigue (p = 0.02), sputum production (p = 0.004), improvement of manifestations observed on chest computed tomography scans (p < 0.00001), incidence of progression to severe COVID-19 (p = 0.003), all-cause mortality (p = 0.003), time to a negative COVID-19 coronavirus test (p < 0.0001), and duration of hospital stay (p = 0.0003). There was no evidence of a difference between herbal medicine added to standard treatment, versus standard treatment alone, on the rate of remission from symptoms such as a fever, sore throat, nasal congestion and discharge, diarrhea, dry throat, chills, and the rate of conversion to a negative COVID-19 coronavirus test. Meta-analysis showed no evidence of a significant difference in adverse events between the two groups. There was an unclear risk of bias across the RCTs included in this analysis, indicating that most studies had methodological limitations. Conclusion: Current evidence suggests that herbal medicine added to standard treatment has potential benefits in the treatment of COVID-19 symptoms but the certainty of evidence was low.
英文关键词	COVID-19 evidence efficacy integrative herbal medicine living review safety
类型	Review
语种	英语
开放获取类型	Green Published, Green Accepted, gold
收录类别	SCI-E
WOS记录号	WOS:000820261900001
WOS关键词	CORONAVIRUS DISEASE 2019 ; CHINESE ; PNEUMONIA ; HEALTH
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/392798
推荐引用方式 GB/T 7714	Ang, Lin,Song, Eunhye,Hu, Xiao-Yang,et al. Herbal Medicine Intervention for the Treatment of COVID-19: A Living Systematic Review and Cumulative Meta-Analysis[J],2022,13.
APA	Ang, Lin,Song, Eunhye,Hu, Xiao-Yang,Lee, Hye Won,Chen, Yaolong,&Lee, Myeong Soo.(2022).Herbal Medicine Intervention for the Treatment of COVID-19: A Living Systematic Review and Cumulative Meta-Analysis.FRONTIERS IN PHARMACOLOGY,13.
MLA	Ang, Lin,et al."Herbal Medicine Intervention for the Treatment of COVID-19: A Living Systematic Review and Cumulative Meta-Analysis".FRONTIERS IN PHARMACOLOGY 13(2022).