干旱区生态环境知识资源中心(Arid): Pan-cancer analysis of CREB3L1 as biomarker in the prediction of prognosis and immunotherapeutic efficacy

Arid

DOI	10.3389/fgene.2022.938510
	Pan-cancer analysis of CREB3L1 as biomarker in the prediction of prognosis and immunotherapeutic efficacy
	Lin, Zhengjun; Wu, Yanlin; Xiao, XunGang; Zhang, Xianghong; Wan, Jia; Zheng, Tao; Chen, Hongxuan; Liu, Tang; Tang, Xianzhe
通讯作者	Liu, T
来源期刊	FRONTIERS IN GENETICS
EISSN	1664-8021
出版年	2022
卷号	13
英文摘要	Background: CAMP response element binding protein 3-like 1 (CREB3L1) has been indicated as a critical biomarker and can modulate multifaced behaviors of tumor cells in diverse cancers. However, a systematic assessment of CREB3L1 in pan-cancer is of absence, and the predictive value of CREB3L1 in cancer prognosis, the tumor immune microenvironment and the efficacy of immunotherapy remains unexplored. Methods: CREB3L1 expression in 33 different cancer types was investigated using RNAseq data from The Cancer Genome Atlas (TCGA) database. The characteristics of CREB3L1 alternations were illustrated in cBioPortal database. The prognostic and clinicopathological value of CREB3L1 was analyzed through clinical data downloaded from the TCGA database. The potential role of CREB3L1 in the tumor immune microenvironment was illustrated by utilizing CIBERSORT and ESTIMATE algorithms, and TISIDB online database. The associations between CREB3L1 expression and tumor mutation burden (TMB), and microsatellite instability (MSI) were assessed by spearman's rank correlation coefficient. Furthermore, Gene Set Enrichment Analysis (GSEA) was conducted to explore the potential biological functions and downstream pathways of CREB3L1 in different human cancers. The correlations of CREB3L1 expression with PD-1/PD-L1 inhibitors efficacy and drug sensitivity were also investigated. Results: The expression of CREB3L1 was abnormally high or low in several different cancer types, and was also strictly associated with the prognosis of cancer patients. CREB3L1 expression levels have a strong relationship with infiltrating immune cells, including regulatory T cells, CD8(+) T cells, macrophages, B naive cells, dendritic cells and mast cells. CREB3L1 expression was also correlated with the expression of multiple immune-related biomolecules, TMB, and MSI in several cancers. Moreover, CREB3L1 had promising applications in predicting the immunotherapeutic benefits and drug sensitivity in cancer management. Conclusions: Our results highlight the value of CREB3L1 as a predictive biomarker for the prognosis and immunotherapy efficacy in multiple cancers, and CREB3L1 seems to play key roles in the tumor immune microenvironment, suggesting the role of CREB3L1 as a promising biomarker for predicting the prognosis and immune-related signatures in diverse cancers.
英文关键词	CREB3L1 pan-cancer prognostic biomarker tumor immune microenvironment immunotherapy efficacy drug sensitivity
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000932881700001
WOS关键词	INFILTRATING IMMUNE CELLS ; MICROSATELLITE INSTABILITY ; EXPRESSION ; OASIS/CREB3L1 ; AUTOPHAGY ; FEATURES ; STRESS ; VIRUS
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/392771
推荐引用方式 GB/T 7714	Lin, Zhengjun,Wu, Yanlin,Xiao, XunGang,et al. Pan-cancer analysis of CREB3L1 as biomarker in the prediction of prognosis and immunotherapeutic efficacy[J],2022,13.
APA	Lin, Zhengjun.,Wu, Yanlin.,Xiao, XunGang.,Zhang, Xianghong.,Wan, Jia.,...&Tang, Xianzhe.(2022).Pan-cancer analysis of CREB3L1 as biomarker in the prediction of prognosis and immunotherapeutic efficacy.FRONTIERS IN GENETICS,13.
MLA	Lin, Zhengjun,et al."Pan-cancer analysis of CREB3L1 as biomarker in the prediction of prognosis and immunotherapeutic efficacy".FRONTIERS IN GENETICS 13(2022).