干旱区生态环境知识资源中心(Arid): Initial characterization of immune microenvironment in pheochromocytoma and paraganglioma

Arid

DOI	10.3389/fgene.2022.1022131
	Initial characterization of immune microenvironment in pheochromocytoma and paraganglioma
	Jin, Bo; Han, Wencong; Guo, Jingjing; Tian, Jie; He, Shiming; Gong, Yanqing; Zhou, Jingcheng; He, Qun; Shen, Qi; Zhang, Zheng
通讯作者	Shen, Q ; Zhang, Z
来源期刊	FRONTIERS IN GENETICS
EISSN	1664-8021
出版年	2022
卷号	13
英文摘要	Due to fewer adverse events, faster onset of action, and longer durable responses compared to chemotherapy, immunotherapy has been widely used to treat advanced solid tumors. Moreover, immunotherapy can improve the autoimmune status, thus allowing patients to benefit from the treatment in the long term. The immune microenvironment status is closely associated with the response to chemotherapies. Here, we analyzed the characteristics of the immune microenvironment in pheochromocytoma and paraganglioma (PPGL). Immunohistochemistry showed that PD-L1 is sparely expressed in PPGL with low positive rates and low expression levels, an expression pattern, that is, not correlated with tumor malignancy. Moreover, the level of intratumoral CD4(+) and CD8(+) lymphocyte infiltration in PPGL is low, suggesting that the immune microenvironment in PPGL may be in immune desertification or immune rejection states in which CD4(+) and CD8(+) lymphocyte infiltration is prevented, rendering immunotherapy less effective. In sum, our results indicate that PPGL is a microsatellite-stable tumor with low tumor mutational burden (TMB) levels, weak neoantigen production, and poor tumor antigenicity, hinting at a poor response of PPGL to chemotherapies.
英文关键词	pheochromocytoma immune microenvironment PD-L1 immunotherapy microsatellite instability
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000901719800001
WOS关键词	MICROSATELLITE-INSTABILITY ; PD-L1 EXPRESSION ; T-CELLS ; CANCER ; TUMORS ; ASSOCIATION
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/392770
推荐引用方式 GB/T 7714	Jin, Bo,Han, Wencong,Guo, Jingjing,et al. Initial characterization of immune microenvironment in pheochromocytoma and paraganglioma[J],2022,13.
APA	Jin, Bo.,Han, Wencong.,Guo, Jingjing.,Tian, Jie.,He, Shiming.,...&Zhang, Zheng.(2022).Initial characterization of immune microenvironment in pheochromocytoma and paraganglioma.FRONTIERS IN GENETICS,13.
MLA	Jin, Bo,et al."Initial characterization of immune microenvironment in pheochromocytoma and paraganglioma".FRONTIERS IN GENETICS 13(2022).