干旱区生态环境知识资源中心(Arid): Clinical characteristics and risk factors associated with ICU-acquired infections in sepsis: A retrospective cohort study

Arid

DOI	10.3389/fcimb.2022.962470
	Clinical characteristics and risk factors associated with ICU-acquired infections in sepsis: A retrospective cohort study
	He, Yajun; Xu, Jiqian; Shang, Xiaopu; Fang, Xiangzhi; Gao, Chenggang; Sun, Deyi; Yao, Lu; Zhou, Ting; Pan, Shangwen; Zou, Xiaojing; Shu, Huaqing; Yang, Xiaobo; Shang, You
通讯作者	Shang, Y
来源期刊	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
ISSN	2235-2988
出版年	2022
卷号	12
英文摘要	Intensive care unit (ICU)-acquired infection is a common cause of poor prognosis of sepsis in the ICU. However, sepsis-associated ICU-acquired infections have not been fully characterized. The study aims to assess the risk factors and develop a model that predicts the risk of ICU-acquired infections in patients with sepsis. MethodsWe retrieved data from the Medical Information Mart for Intensive Care (MIMIC) IV database. Patients were randomly divided into training and validation cohorts at a 7:3 ratio. A multivariable logistic regression model was used to identify independent risk factors that could predict ICU-acquired infection. We also assessed its discrimination and calibration abilities and compared them with classical score systems. ResultsOf 16,808 included septic patients, 2,871 (17.1%) developed ICU-acquired infection. These patients with ICU-acquired infection had a 17.7% ICU mortality and 31.8% in-hospital mortality and showed a continued rise in mortality from 28 to 100 days after ICU admission. The classical Systemic Inflammatory Response Syndrome Score (SIRS), Sequential Organ Failure Assessment (SOFA), Oxford Acute Severity of Illness Score (OASIS), Simplified Acute Physiology Score II (SAPS II), Logistic Organ Dysfunction Score (LODS), Charlson Comorbidity Index (CCI), and Acute Physiology Score III (APS III) scores were associated with ICU-acquired infection, and cerebrovascular insufficiency, Gram-negative bacteria, surgical ICU, tracheostomy, central venous catheter, urinary catheter, mechanical ventilation, red blood cell (RBC) transfusion, LODS score and anticoagulant therapy were independent predictors of developing ICU-acquired infection in septic patients. The nomogram on the basis of these independent predictors showed good calibration and discrimination in both the derivation (AUROC = 0.737; 95% CI, 0.725-0.749) and validation (AUROC = 0.751; 95% CI, 0.734-0.769) populations and was superior to that of SIRS, SOFA, OASIS, SAPS II, LODS, CCI, and APS III models. ConclusionsICU-acquired infections increase the likelihood of septic mortality. The individualized prognostic model on the basis of the nomogram could accurately predict ICU-acquired infection and optimize management or tailored therapy.
英文关键词	sepsis ICU-acquired infection risk factors prediction MIMIC database
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000839410200001
WOS关键词	STROKE-INDUCED IMMUNODEPRESSION ; INTENSIVE-CARE-UNIT ; SECONDARY INFECTIONS ; INDUCED IMMUNOSUPPRESSION ; TRANSFUSION ; MORTALITY ; EXPRESSION ; BACTERIAL
WOS类目	Immunology ; Microbiology
WOS研究方向	Immunology ; Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/392671
推荐引用方式 GB/T 7714	He, Yajun,Xu, Jiqian,Shang, Xiaopu,et al. Clinical characteristics and risk factors associated with ICU-acquired infections in sepsis: A retrospective cohort study[J],2022,12.
APA	He, Yajun.,Xu, Jiqian.,Shang, Xiaopu.,Fang, Xiangzhi.,Gao, Chenggang.,...&Shang, You.(2022).Clinical characteristics and risk factors associated with ICU-acquired infections in sepsis: A retrospective cohort study.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,12.
MLA	He, Yajun,et al."Clinical characteristics and risk factors associated with ICU-acquired infections in sepsis: A retrospective cohort study".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 12(2022).