干旱区生态环境知识资源中心(Arid): CREB3L1 and CREB3L2 control Golgi remodelling during decidualization of endometrial stromal cells

Arid

DOI	10.3389/fcell.2022.986997
	CREB3L1 and CREB3L2 control Golgi remodelling during decidualization of endometrial stromal cells
	Pittari, Daniele; Dalla Torre, Marco; Borini, Elena; Hummel, Barbara; Sawarkar, Ritwick; Semino, Claudia; van Anken, Eelco; Panina-Bordignon, Paola; Sitia, Roberto; Anelli, Tiziana
通讯作者	Anelli, T
来源期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN	2296-634X
出版年	2022
卷号	10
英文摘要	Upon progesterone stimulation, Endometrial Stromal Cells (EnSCs) undergo a differentiation program into secretory cells (decidualization) to release in abundance factors crucial for embryo implantation. We previously demonstrated that decidualization requires massive reshaping of the secretory pathway and, in particular, of the Golgi complex. To decipher the underlying mechanisms, we performed a time-course transcriptomic analysis of in vitro decidualizing EnSC. Pathway analysis shows that Gene Ontology terms associated with vesicular trafficking and early secretory pathway compartments are the most represented among those enriched for upregulated genes. Among these, we identified a cluster of co-regulated genes that share CREB3L1 and CREB3L2 binding elements in their promoter regions. Indeed, both CREB3L1 and CREB3L2 transcription factors are up-regulated during decidualization. Simultaneous downregulation of CREB3L1 and CREB3L2 impairs Golgi enlargement, and causes dramatic changes in decidualizing EnSC, including Golgi fragmentation, collagen accumulation in dilated Endoplasmic Reticulum cisternae, and overall decreased protein secretion. Thus, both CREB3L1 and CREB3L2 are required for Golgi reshaping and efficient protein secretion, and, as such, for successful decidualization.
英文关键词	secretory pathway vesicular transport differentiation transcriptomics analysis collagen
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000876609000001
WOS关键词	PROTEIN-QUALITY CONTROL ; TRANSCRIPTION FACTOR ; STRESS ; DIFFERENTIATION ; CAPACITY ; COLLAGEN ; PATHWAY ; OASIS ; ER
WOS类目	Cell Biology ; Developmental Biology
WOS研究方向	Cell Biology ; Developmental Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/392670
推荐引用方式 GB/T 7714	Pittari, Daniele,Dalla Torre, Marco,Borini, Elena,et al. CREB3L1 and CREB3L2 control Golgi remodelling during decidualization of endometrial stromal cells[J],2022,10.
APA	Pittari, Daniele.,Dalla Torre, Marco.,Borini, Elena.,Hummel, Barbara.,Sawarkar, Ritwick.,...&Anelli, Tiziana.(2022).CREB3L1 and CREB3L2 control Golgi remodelling during decidualization of endometrial stromal cells.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,10.
MLA	Pittari, Daniele,et al."CREB3L1 and CREB3L2 control Golgi remodelling during decidualization of endometrial stromal cells".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10(2022).