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DOI	10.1007/s11356-022-19577-1
	A sensitive, robust method for determining natural and synthetic hormones in surface and wastewaters by continuous solid-phase extraction-gas chromatography-mass spectrometry
	Chafi, Safae; Ballesteros, Evaristo
通讯作者	Ballesteros, E
来源期刊	ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
ISSN	0944-1344
EISSN	1614-7499
出版年	2022
卷号	29 期号:35 页码:53619-53632
英文摘要	Over recent decades, steroidal estrogens have become an emerging and very serious issue as they pose a serious threat to living organisms, soil, plants, and water resources in general. Estrogens have therefore been the subject of considerable scientific attention in order to develop new methodologies for its determination, being able of detecting them at very low concentrations. Those procedures minimize or eliminate the consumption of organic solvents and reagents that may be incompatible with the environment. In this respect, we developed a sensitive, selective method for the simultaneous determination of thirteen natural and synthetic hormones present at the nanogram-per-liter level in various types of water by using continuous solid-phase extraction in combination with gas chromatography and mass spectrometry (GC-MS). The target analytes were preferentially sorbed on an Oasis HLB sorbent column (80 mg) and eluted with acetone (600 mu L) for derivatization with a mixture of 70 mu L of N,O-bis(trimethylsilyl) trifluoroacetamide and trimethylchlorosilane and 35 mu L of petroleum ether in a household microwave oven at 200 W for 4 min. Under optimum conditions, the ensuing method exhibited good linearity (r >= 0.998), good precision (RSD <= 7%), high recoveries (92-103%), and low detection limits (0.01-0.3 ng L-1). The method outperforms existing alternatives in robustness, sensitivity, throughput, flexibility-it allows both estrogens, progestogens, and androgens to be determined simultaneously-and compliance with the principles of Green Chemistry. It was successfully used to analyze various types of water samples (mineral, tap, well, pond, swimming pool, river, and waste) that were found to contain four estrogens (estrone, 17 beta-estradiol, 17 alpha-ethinylestradiol, and hexestrol), two progestogens (testosterone, dihydrotestosterone), and one progestogen (progesterone) at concentrations ranging from 3.0 to 110 ng L-1.
英文关键词	Natural and synthetic hormones Water Continuous solid-phase extraction Microwave-assisted derivatization Gas chromatography-mass spectrometry
类型	Article
语种	英语
开放获取类型	Green Published, hybrid
收录类别	SCI-E
WOS记录号	WOS:000769296200014
WOS关键词	NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; ENDOCRINE DISRUPTING COMPOUNDS ; WATER SAMPLES ; WASTE-WATER ; ESTROGENIC HORMONES ; ANDROGENS ; DERIVATIZATION ; PROGESTINS ; PROGESTOGENS ; STEROIDS
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/392518
推荐引用方式 GB/T 7714	Chafi, Safae,Ballesteros, Evaristo. A sensitive, robust method for determining natural and synthetic hormones in surface and wastewaters by continuous solid-phase extraction-gas chromatography-mass spectrometry[J],2022,29(35):53619-53632.
APA	Chafi, Safae,&Ballesteros, Evaristo.(2022).A sensitive, robust method for determining natural and synthetic hormones in surface and wastewaters by continuous solid-phase extraction-gas chromatography-mass spectrometry.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,29(35),53619-53632.
MLA	Chafi, Safae,et al."A sensitive, robust method for determining natural and synthetic hormones in surface and wastewaters by continuous solid-phase extraction-gas chromatography-mass spectrometry".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 29.35(2022):53619-53632.