干旱区生态环境知识资源中心(Arid): Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila

Arid

DOI	10.1016/j.cub.2022.02.063
	Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila
	Dweck, Hany K. M.; Talross, Gaelle J. S.; Luo, Yichen; Ebrahim, Shimaa A. M.; Carlson, John R.
通讯作者	Carlson, JR
来源期刊	CURRENT BIOLOGY
ISSN	0960-9822
EISSN	1879-0445
出版年	2022
卷号	32 期号:8 页码:1776-+
英文摘要	Salt taste is one of the most ancient of all sensory modalities. However, the molecular basis of salt taste remains unclear in invertebrates. Here, we show that the response to low, appetitive salt concentrations in Drosophila depends on Ir56b, an atypical member of the ionotropic receptor (Ir) family. Ir56b acts in concert with two coreceptors, Ir25a and Ir76b. Mutation of Ir56b virtually eliminates an appetitive behavioral response to salt. Ir56b is expressed in neurons that also sense sugars via members of the Gr (gustatory receptor) family. Misexpression of Ir56b in bitter-sensing neurons confers physiological responses to appetitive doses of salt. Ir56b is unique among tuning Irs in containing virtually no N-terminal region, a feature that is evolutionarily conserved. Moreover, Ir56b is a ???pseudo-pseudogene???: its coding sequence contains a premature stop codon that can be replaced with a sense codon without loss of function. This stop codon is conserved among many Drosophila species but is absent in a number of species associated with cactus in arid regions. Thus, Ir56b serves the evolutionarily ancient function of salt detection in neurons that underlie both salt and sweet taste modalities.
类型	Article
语种	英语
开放获取类型	Green Accepted, hybrid
收录类别	SCI-E
WOS记录号	WOS:000800107000009
WOS关键词	BITTER TASTE ; DIVERGENCE TIMES ; CANDIDATE TASTE ; MELANOGASTER ; SIMULANS ; CHEMORECEPTORS ; PHYLOGENY ; SEQUENCE ; GENES
WOS类目	Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/392203
推荐引用方式 GB/T 7714	Dweck, Hany K. M.,Talross, Gaelle J. S.,Luo, Yichen,et al. Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila[J],2022,32(8):1776-+.
APA	Dweck, Hany K. M.,Talross, Gaelle J. S.,Luo, Yichen,Ebrahim, Shimaa A. M.,&Carlson, John R..(2022).Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila.CURRENT BIOLOGY,32(8),1776-+.
MLA	Dweck, Hany K. M.,et al."Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila".CURRENT BIOLOGY 32.8(2022):1776-+.