干旱区生态环境知识资源中心(Arid): Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis

Arid

DOI	10.1038/s42003-022-03709-x
	Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis
	Miyake, Yoshiaki; Obana, Masanori; Yamamoto, Ayaha; Noda, Shunsuke; Tanaka, Koki; Sakai, Hibiki; Tatsumoto, Narihito; Makino, Chihiro; Kanemoto, Soshi; Shioi, Go; Tanaka, Shota; Maeda, Makiko; Okada, Yoshiaki; Imaizumi, Kazunori; Asanuma, Katsuhiko; Fujio, Yasushi
通讯作者	Obana, M
来源期刊	COMMUNICATIONS BIOLOGY
EISSN	2399-3642
出版年	2022
卷号	5 期号:1
英文摘要	Upregulation of transcription factor OASIS in podocytes contributes to podocyte and/or tubular injury through decreased PRKCi expression and is a critical event for the disturbance of kidney homeostasis. Podocyte injury is involved in the onset and progression of various kidney diseases. We previously demonstrated that the transcription factor, old astrocyte specifically induced substance (OASIS) in myofibroblasts, contributes to kidney fibrosis, as a novel role of OASIS in the kidneys. Importantly, we found that OASIS is also expressed in podocytes; however, the pathophysiological significance of OASIS in podocytes remains unknown. Upon lipopolysaccharide (LPS) treatment, there is an increase in OASIS in murine podocytes. Enhanced serum creatinine levels and tubular injury, but not albuminuria and podocyte injury, are attenuated upon podocyte-restricted OASIS knockout in LPS-treated mice, as well as diabetic mice. The protective effects of podocyte-specific OASIS deficiency on tubular injury are mediated by protein kinase C iota (PRKCI/PKC iota), which is negatively regulated by OASIS in podocytes. Furthermore, podocyte-restricted OASIS transgenic mice show tubular injury and tubulointerstitial fibrosis, with severe albuminuria and podocyte degeneration. Finally, there is an increase in OASIS-positive podocytes in the glomeruli of patients with minimal change nephrotic syndrome and diabetic nephropathy. Taken together, OASIS in podocytes contributes to podocyte and/or tubular injury, in part through decreased PRKCI. The induction of OASIS in podocytes is a critical event for the disturbance of kidney homeostasis.
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000829081800001
WOS关键词	PROTEIN-KINASE-C ; FILTRATION BARRIER ; APKC-LAMBDA/IOTA ; EXPRESSION ; POLARITY ; DIFFERENTIATION ; OVEREXPRESSION ; MACROPHAGES ; OASIS
WOS类目	Biology ; Multidisciplinary Sciences
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/392169
推荐引用方式 GB/T 7714	Miyake, Yoshiaki,Obana, Masanori,Yamamoto, Ayaha,et al. Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis[J],2022,5(1).
APA	Miyake, Yoshiaki.,Obana, Masanori.,Yamamoto, Ayaha.,Noda, Shunsuke.,Tanaka, Koki.,...&Fujio, Yasushi.(2022).Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis.COMMUNICATIONS BIOLOGY,5(1).
MLA	Miyake, Yoshiaki,et al."Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis".COMMUNICATIONS BIOLOGY 5.1(2022).