干旱区生态环境知识资源中心(Arid): Combined Serum NGAL and Fetuin-A to Predict 28-Day Mortality in Patients with Sepsis and Risk Prediction Model Construction

Arid

DOI	10.14715/cmb/2022.68.11.9
	Combined Serum NGAL and Fetuin-A to Predict 28-Day Mortality in Patients with Sepsis and Risk Prediction Model Construction
	Liu, Yutong; Bu, Lin; Chao, Yali; Wang, Houqing
通讯作者	Wang, HQ
来源期刊	CELLULAR AND MOLECULAR BIOLOGY
ISSN	0145-5680
EISSN	1165-158X
出版年	2022
卷号	68 期号:11 页码:47-52
英文摘要	It was to investigate the predictive value of NGAL and Fetuin-A for 28-day mortality in patients with sepsis, and to construct a mortality risk prediction model. 120 patients admitted to The Affiliated Hospital of Xuzhou Medical University Hospital were grouped. Serum biochemical parameters were measured and scale scores were performed. The patient data were divided into a training set and test set in a ratio of 7:3, and the logistic regression model and random forest model were included to evaluate the 28-day mortality prediction efficacy of each index and model. The results showed that WBC, PLT, RBCV, and PLR decreased, SCr, Lac, PCT, D-dimer, NPR, NGAL, and Fetuin-A increased, APACHE II scale, SOFA scale, and OASIS scale scores increased in the death group (P < 0.05). SCr > 408 mu mol/L, Lac > 2.3 mmol/L, PCT > 30 ng/mL, D-dimer > 2.33 mg/L, PLR > 190, APACHE II > 18 points, SOFA > 2, OASIS > 30, NGAL > 352 mg/L, and Fetuin-A > 0.32 g/L were found to be risk factors for 28-day death, while WBC > 12 x 109/L, PLT > 172 x 103/mu L, and RBCV > 30% were found to be protective factors for 28-day mortality. The predicted AUCs of APACHE II, SOFA, OASIS, NGAL, Fetuin-A, NGAL & Fetuin-A, logistic regression model, and random forest model were 0.80, 0.71, 0.77, 0.69, 0.86, 0.92, 0.83, and 0.81. NGAL combined with Fetuin-A has good prediction efficacy in 28-day mortality in septic patients. Copyright: (c) 2022 by the C.M.B. Association. All rights reserved.
英文关键词	Sepsis NGAL Fetuin-A 28-day mortality
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000973809600008
WOS关键词	ACUTE KIDNEY INJURY ; INFLAMMATION
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/392125
推荐引用方式 GB/T 7714	Liu, Yutong,Bu, Lin,Chao, Yali,et al. Combined Serum NGAL and Fetuin-A to Predict 28-Day Mortality in Patients with Sepsis and Risk Prediction Model Construction[J],2022,68(11):47-52.
APA	Liu, Yutong,Bu, Lin,Chao, Yali,&Wang, Houqing.(2022).Combined Serum NGAL and Fetuin-A to Predict 28-Day Mortality in Patients with Sepsis and Risk Prediction Model Construction.CELLULAR AND MOLECULAR BIOLOGY,68(11),47-52.
MLA	Liu, Yutong,et al."Combined Serum NGAL and Fetuin-A to Predict 28-Day Mortality in Patients with Sepsis and Risk Prediction Model Construction".CELLULAR AND MOLECULAR BIOLOGY 68.11(2022):47-52.