干旱区生态环境知识资源中心(Arid): Hippocampus-based static functional connectivity mapping within white matter in mild cognitive impairment

Arid

DOI	10.1007/s00429-022-02521-x
	Hippocampus-based static functional connectivity mapping within white matter in mild cognitive impairment
	Jiang, Yuan; Wang, Pan; Wen, Jiaping; Wang, Jianlin; Li, Hongyi; Biswal, Bharat B.
通讯作者	Wang, P ; Biswal, BB
来源期刊	BRAIN STRUCTURE & FUNCTION
ISSN	1863-2653
EISSN	1863-2661
出版年	2022
卷号	227 期号:7 页码:2285-2297
英文摘要	Mild cognitive impairment (MCI) is clinically characterized by memory loss and cognitive impairment closely associated with the hippocampal atrophy. Accumulating studies have confirmed the presence of neural signal changes within white matter (WM) in resting-state functional magnetic resonance imaging (fMRI). However, it remains unclear how abnormal hippocampus activity affects the WM regions in MCI. The current study employs 43 MCI, 71 very MCI (VMCI) and 87 age-, gender-, and education-matched healthy controls (HCs) from the public OASIS-3 dataset. Using the left and right hippocampus as seed points, we obtained the whole-brain functional connectivity (FC) maps for each subject. We then perform one-way ANOVA analysis to investigate the abnormal FC regions among HCs, VMCI, and MCI. We further performed probabilistic tracking to estimate whether the abnormal FC correspond to structural connectivity disruptions. Compared to HCs, MCI and VMCI groups exhibited reduced FC in the right middle temporal gyrus within gray matter, and right temporal pole, right inferior frontal gyrus within white matter. Specific dysconnectivity is shown in the cerebellum Crus II, left inferior temporal gyrus within gray matter, and right frontal gyrus within white matter. In addition, the fiber bundles connecting the left hippocampus and right temporal pole within white matter show abnormally increased mean diffusivity in MCI. The current study proposes a new functional imaging direction for exploring the mechanism of memory decline and pathophysiological mechanisms in different stages of Alzheimer's disease.
英文关键词	Alzheimer's disease Functional connectivity Hippocampus Mild cognitive impairment White matter
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000828432700001
WOS关键词	ALZHEIMERS-DISEASE ; BRAIN ACTIVITY ; PLASTICITY ; NETWORKS ; ATROPHY ; MEMORY
WOS类目	Anatomy & Morphology ; Neurosciences
WOS研究方向	Anatomy & Morphology ; Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/392032
推荐引用方式 GB/T 7714	Jiang, Yuan,Wang, Pan,Wen, Jiaping,et al. Hippocampus-based static functional connectivity mapping within white matter in mild cognitive impairment[J],2022,227(7):2285-2297.
APA	Jiang, Yuan,Wang, Pan,Wen, Jiaping,Wang, Jianlin,Li, Hongyi,&Biswal, Bharat B..(2022).Hippocampus-based static functional connectivity mapping within white matter in mild cognitive impairment.BRAIN STRUCTURE & FUNCTION,227(7),2285-2297.
MLA	Jiang, Yuan,et al."Hippocampus-based static functional connectivity mapping within white matter in mild cognitive impairment".BRAIN STRUCTURE & FUNCTION 227.7(2022):2285-2297.