干旱区生态环境知识资源中心(Arid): Network Pharmacology-Based Study on the Efficacy and Mechanism of Lonicera japonica Thunberg

Arid

DOI	10.3390/app12189122
	Network Pharmacology-Based Study on the Efficacy and Mechanism of Lonicera japonica Thunberg
	Park, Sang Jun; Kim, Mi Hye; Yang, Woong Mo
通讯作者	Yang, WM
来源期刊	APPLIED SCIENCES-BASEL
EISSN	2076-3417
出版年	2022
卷号	12 期号:18
英文摘要	Network pharmacology is an emerging method for investigating the potential effects and mechanisms of natural products through system-level analyses of gene sets in herbs. Lonicera japonica Thunberg (LJ) is known to have anti-inflammatory, anti-bacterial, anti-oxidant, anti-tumor and neuroprotective effects. In the present study, network pharmacological analysis was performed to assess the potential efficacy and mechanisms of LJ. First of all, constituents of LJ were gathered from public databases: the Oriental Advanced Searching Integrated System (OASIS) database, PubChem and the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database. Then, a network was constructed using Cytoscape3.8.2, which visualizes biomedical interactions, and a functional enrichment analysis was conducted to uncover the pathways most relevant to LJ through Enrichr based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway 2021. Further, we performed a study of the literature to determine whether the results of our study were consistent with those of previous studies. The results showed that 'Advanced glycation end products-Receptor for advanced glycation end products (AGE-RAGE) signaling pathway in diabetic complications' was the pathway most relevant to LJ, especially through 'Mitogen-activated protein kinase (MAPK) signaling pathway', 'Phosphatidylinositol 3 kinase-Protein kinase B (PI3K-AKT) signaling pathway' and 'Janus kinase-Signal transducers and activators of transcription (JAK-STAT) signaling pathway'. Based on the literature study, LJ showed relevance to MAPK, PI3K-AKT and JAK-STAT and was associated with therapeutic effects on diabetes and diabetic complications. This study shows that network pharmacology can be a suitable approach for analyzing LJ and suggests the potential efficacy and mechanisms of LJ.
英文关键词	Lonicera japonica Thunberg network pharmacology potential efficacy age-rage signaling pathway diabetic complications
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000856220500001
WOS关键词	KAPPA-B ; EXTRACT ; IDENTIFICATION ; ACTIVATION ; PI3K/AKT ; CELLS
WOS类目	Chemistry, Multidisciplinary ; Engineering, Multidisciplinary ; Materials Science, Multidisciplinary ; Physics, Applied
WOS研究方向	Chemistry ; Engineering ; Materials Science ; Physics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/391867
推荐引用方式 GB/T 7714	Park, Sang Jun,Kim, Mi Hye,Yang, Woong Mo. Network Pharmacology-Based Study on the Efficacy and Mechanism of Lonicera japonica Thunberg[J],2022,12(18).
APA	Park, Sang Jun,Kim, Mi Hye,&Yang, Woong Mo.(2022).Network Pharmacology-Based Study on the Efficacy and Mechanism of Lonicera japonica Thunberg.APPLIED SCIENCES-BASEL,12(18).
MLA	Park, Sang Jun,et al."Network Pharmacology-Based Study on the Efficacy and Mechanism of Lonicera japonica Thunberg".APPLIED SCIENCES-BASEL 12.18(2022).