干旱区生态环境知识资源中心(Arid): A comparison of clinical manifestations of Japanese encephalitis between children and adults in Gansu Province, Northwest China (2005-2020)

Arid

DOI	10.1016/j.actatropica.2022.106449
	A comparison of clinical manifestations of Japanese encephalitis between children and adults in Gansu Province, Northwest China (2005-2020)
	Li, Donghua; Zhang, Xiaoshu; Shi, Tianshan; Jin, Na; Zhao, Xiangkai; Meng, Lei; Liu, Yanchen; Zheng, Hongmiao; Zhao, Xin; Li, Juansheng; Shen, Xiping; Ren, Xiaowei
通讯作者	Ren, XW
来源期刊	ACTA TROPICA
ISSN	0001-706X
EISSN	1873-6254
出版年	2022
卷号	231
英文摘要	Japanese encephalitis (JE), a mosquito-borne zoonotic disease, has emerged as a major public health concern around the world. Previous research has shown that JE has serious sequelae, and the recent shift in the population from children to adults presents a significant challenge for JE treatment and prevention. Therefore, we examined the differences in clinical manifestations (clinical symptoms, clinical signs, complications, and clinical typing) of JE between children and adults over the 15 years in Gansu Province to provide a theoretical basis for better response to JE treatment. Clinical typing was found to be statistically significant in the child versus adult groups and the groups with or without vaccination. Only the dysfunction of consciousness differed statistically between children with and without vaccination, whereas neurological symptoms such as vomiting (jet vomiting), irritability, drowsiness, convulsions, and hyperspasmia differed statistically between children and adults, and the rest of the symptoms did not differ statistically. Only pupil size changes were statistically different in clinical signs between the children with and without vaccination, while blood pressure changes, change in pupil size, positive meningeal stimulation signs, and positive pathological reflexes (increased muscle tone and Babinski's sign) were statistically different between adults and children. Bronchopneumonia was the most common complication, especially in adults. Therefore, the authors believe that children and adults differ in some clinical manifestations and propose that efforts should be directed toward developing individualized treatment plans for different age groups and employing more effective supportive treatment for various populations. In addition, we suggest expanding the coverage of the JE vaccine and increasing overall vaccination rates and adopting multiple measures in conjunction with JE prevention and control.
英文关键词	Japanese encephalitis Arid and semi-arid areas Adult Children Differences in clinical manifestations
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000793252200001
WOS关键词	FEATURES ; SURVEILLANCE ; OUTBREAK
WOS类目	Parasitology ; Tropical Medicine
WOS研究方向	Parasitology ; Tropical Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/391540
推荐引用方式 GB/T 7714	Li, Donghua,Zhang, Xiaoshu,Shi, Tianshan,et al. A comparison of clinical manifestations of Japanese encephalitis between children and adults in Gansu Province, Northwest China (2005-2020)[J],2022,231.
APA	Li, Donghua.,Zhang, Xiaoshu.,Shi, Tianshan.,Jin, Na.,Zhao, Xiangkai.,...&Ren, Xiaowei.(2022).A comparison of clinical manifestations of Japanese encephalitis between children and adults in Gansu Province, Northwest China (2005-2020).ACTA TROPICA,231.
MLA	Li, Donghua,et al."A comparison of clinical manifestations of Japanese encephalitis between children and adults in Gansu Province, Northwest China (2005-2020)".ACTA TROPICA 231(2022).